DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and Eif4e1b

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001273108.1	Gene:	Eif4e1b / 218268	MGIID:	2685119	Length:	250	Species:	Mus musculus

Alignment Length:	232	Identity:	93/232 - (40%)
Similarity:	138/232 - (59%)	Gaps:	28/232 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EPPTSAAA----PAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEH----LYK-HPLMNV 86
            |.|:.|.|    ..||||:            .|:..|....|     ..||    |.| |||...
Mouse    29 EKPSEATAEGVQAGEAKDL------------PGSLKTQRRKA-----HREHPPEVLSKLHPLQYR 76

  Fly    87 WTLWYLENDRSKSWEDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAAN 151
            |.||:.:||||::|:|....:|.|:||||||::|:|||..|::..|.||:|||:.|.|||||..|
Mouse    77 WVLWFFKNDRSRAWQDNLQLVTKFNTVEDFWAVYSHIKLASKLSSGCDYALFKEGILPMWEDNRN 141

  Fly   152 KQGGRWVITLNKSSK-TDLDNLWLDVLLCLIGEAF-DHSDQICGAVINIRGKSNKISIWTADGNN 214
            ||||||:::::|..: .:||.|||:.||||:|..| ::|.::||||:|||.|.:||::||::..:
Mouse   142 KQGGRWLLSIDKQLRHFELDRLWLETLLCLVGNCFEEYSREVCGAVVNIRTKRDKIALWTSEAED 206

  Fly   215 EEAALEIGHKLRDALRLGRNNSLQYQLHKDTMVKQGS 251
            :...::||...::.|.:.....:.||.|.||..|..:
Mouse   207 KAGVMQIGQIYKERLGISTKTIIGYQAHADTAAKSNN 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	71/158 (45%)
Eif4e1b	NP_001273108.1	IF4E	75..231	CDD:279921	69/155 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830790
Domainoid	1	1.000	186	1.000	Domainoid score	I3337
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8694
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800