DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and ife-3

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_503123.1	Gene:	ife-3 / 178536	WormBaseID:	WBGene00002061	Length:	251	Species:	Caenorhabditis elegans

Alignment Length:	199	Identity:	92/199 - (46%)
Similarity:	130/199 - (65%)	Gaps:	5/199 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TATTTAPAGDDAVRTEHLYKHPLMNVWTLWYLENDRSKSWEDMQNEITSFDTVEDFWSLYNHIKP 125
            :|:....|.|.:|..|.|.:|||.|.|.||||:.||:|.|||....::.||||||||||||||:.
Worm    12 SASGDVNASDASVPPELLTRHPLQNRWALWYLKADRNKEWEDCLKMVSLFDTVEDFWSLYNHIQS 76

  Fly   126 PSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWVITLNKSS---KTD-LDNLWLDVLLCLIGEAFD 186
            ...:..||||.|||:.|:|||||..|.|||||::.::|..   :|. ||:.||::|:.::||.||
Worm    77 AGGLNWGSDYYLFKEGIKPMWEDVNNVQGGRWLVVVDKQKLQRRTQLLDHYWLELLMAIVGEQFD 141

  Fly   187 -HSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDALRLGRNNSLQYQLHKDTMVKQG 250
             :.|.|||||:|:|.|.:|:|:||.|...::..|.||..|:..|.:.....|:|::|||:..:..
Worm   142 EYGDYICGAVVNVRQKGDKVSLWTRDATRDDVNLRIGQVLKQKLSIPDTEILRYEVHKDSSARTS 206

  Fly   251 SNVK 254
            |.||
Worm   207 STVK 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	78/161 (48%)
ife-3	NP_503123.1	IF4E	36..195	CDD:279921	76/158 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156151
Domainoid	1	1.000	173	1.000	Domainoid score	I2208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	197	1.000	Inparanoid score	I2501
Isobase	1	0.950	-	0	Normalized mean entropy	S964
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		otm14399
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	LDO	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890