DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and Eif4e

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	XP_006501056.1	Gene:	Eif4e / 13684	MGIID:	95305	Length:	230	Species:	Mus musculus

Alignment Length:	247	Identity:	110/247 - (44%)
Similarity:	142/247 - (57%)	Gaps:	29/247 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KSMFKTSAPSTEQGRPEPPTSAAAPAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEHLY 79
            :|...|..|.|      .||:...|||.:..   |..||...|                  ||..
Mouse    11 RSKMATVEPET------TPTTNPPPAEEEKT---ESNQEVANP------------------EHYI 48

  Fly    80 KHPLMNVWTLWYLENDRSKSWEDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRP 144
            ||||.|.|.||:.:||:||:|:.....|:.||||||||:|||||:..|.:..|.||||||..|.|
Mouse    49 KHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP 113

  Fly   145 MWEDAANKQGGRWVITLNKSS-KTDLDNLWLDVLLCLIGEAF-DHSDQICGAVINIRGKSNKISI 207
            ||||..||:||||:|||||.. ::|||..||:.|||||||:| |:||.:||||:|:|.|.:||:|
Mouse   114 MWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAI 178

  Fly   208 WTADGNNEEAALEIGHKLRDALRLGRNNSLQYQLHKDTMVKQGSNVKSIYTL 259
            ||.:..|.:|...||...::.|.|.....:.||.|.||..|.||..|:.:.:
Mouse   179 WTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	84/158 (53%)
Eif4e	XP_006501056.1	IF4E	51..210	CDD:366742	84/158 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830799
Domainoid	1	1.000	186	1.000	Domainoid score	I3337
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3600
Isobase	1	0.950	-	0	Normalized mean entropy	S964
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8694
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	LDO	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750