Protein Alignment eIF4E1 and Eif4e

DIOPT Version :10

• Sequence 1: NP_524829.1
• Gene: eIF4E1 / 45525
• FlyBaseID: FBgn0015218
• Length: 259
• Species: Drosophila melanogaster
• Sequence 2: NP_446426.1
• Gene: Eif4e / 117045
• RGDID: 69647
• Length: 217
• Species: Rattus norvegicus
• Alignment Length: 233
• Identity: 108/233 - (46%)
• Similarity: 139/233 - (59%)
• Gaps: 24/233 - (10%)

  Fly    30 PE-PPTSAAAPAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEHLYKHPLMNVWTLWYLE 93
            || .||:...|||.:..   |..||...|                  ||..||||.|.|.||:.:
  Rat     6 PETTPTTNPPPAEEEKT---ESNQEVANP------------------EHYIKHPLQNRWALWFFK 49

  Fly    94 NDRSKSWEDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWV 158
            ||:||:|:.....|:.||||||||:|||||:..|.:..|.||||||..|.|||||..||:||||:
  Rat    50 NDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWL 114

  Fly   159 ITLNKSS-KTDLDNLWLDVLLCLIGEAF-DHSDQICGAVINIRGKSNKISIWTADGNNEEAALEI 221
            |||||.. ::|||..||:.|||||||:| |:||.:||||:|:|.|.:||:|||.:..|.:|...|
  Rat   115 ITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHI 179

  Fly   222 GHKLRDALRLGRNNSLQYQLHKDTMVKQGSNVKSIYTL 259
            |...::.|.|.....:.||.|.||..|.||..|:.:.:
  Rat   180 GRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_524829.1	IF4E	82..239	CDD:460281	84/158 (53%)
Eif4e	NP_446426.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		8/23 (35%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250|UniProtKB:P06730	37..40		2/2 (100%)
		IF4E	38..197	CDD:460281	84/158 (53%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250|UniProtKB:P06730	73..77		2/3 (67%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250|UniProtKB:P06730	132..139		4/6 (67%)