DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and DIT2

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	462	Identity:	103/462 - (22%)
Similarity:	194/462 - (41%)	Gaps:	100/462 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YSRERAKEMGTSYIEYVFGKAIYNII------------DADSAENVLNHPNLITKGLVYNFLHPF 124
            |.||..::.|.  :::.||.. :||:            |.|:.....|.     |.:.|:.|..:
Yeast    58 YIRESMEKYGA--VKFFFGSR-WNILVSRSEYLAQIFKDEDTFAKSGNQ-----KKIPYSALAAY 114

  Fly   125 LRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQE--IFKTESQKFLLQ------FEGQDEVTITL 181
            ....::::.|..|...|..:|     |.|..|.:  |||  :.|.|..      .|||  .:|.:
Yeast   115 TGDNVISAYGAVWRNYRNAVT-----NGLQHFDDAPIFK--NAKILCTLIKNRLLEGQ--TSIPM 170

  Fly   182 HDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAAKDF 246
            ..:..|..|::|.:.|:|.....:..:.:.:.|:..:|:    :::.:|         .|....|
Yeast   171 GPLSQRMALDNISQVALGFDFGALTHEKNAFHEHLIRIK----KQIFHP---------FFLTFPF 222

  Fly   247 ASALDVVHRFSS--------EIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDG 303
            ...|.:..|..:        |::.||   ::|||..:..       ..:..||..| ||.|..:.
Yeast   223 LDVLPIPSRKKAFKDVVSFRELLVKR---VQDELVNNYK-------FEQTTFAASD-LIRAHNNE 276

  Fly   304 LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCY------QEIQEHIDDDLSNL- 361
            :||:..:.:.:..::..|::...:     |.|.||        |      .|.||.:..:::.:
Yeast   277 IIDYKQLTDNIVIILVAGHENPQL-----LFNSSL--------YLLAKYSNEWQEKLRKEVNGIT 328

  Fly   362 DVGQLNKLKYLEYFMKETTRLFPSV-PIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYW 425
            |...|..|..|..|:.|..|::|.: .|:.|...:..:|...:::|||..:..:.|....:.|.|
Yeast   329 DPKGLADLPLLNAFLFEVVRMYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTW 393

  Fly   426 -DSPEEFRPERFLPENVQDRHTY-------AYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKV 482
             .:.::|:|||:..:....|..:       |...|..|:|.|:|:|.|:.||:..:..:||||:
Yeast   394 GTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFR- 457

  Fly   483 LKAIDPQ 489
             .::||:
Yeast   458 -WSLDPE 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	103/462 (22%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	100/455 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I1605
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050