Protein Alignment Cyp4p1 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 160/553 - (28%)
• Similarity: 243/553 - (43%)
• Gaps: 109/553 - (19%)

  Fly     5 WLIL-------ALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLY 62
            ||:|       .|:.:|.|.:         :|:....||      :......|....:|
Human    19 WLLLLLVVGSWLLARILAWTY---------AFYNNCRRL------QCFPQPPKRNWFWG------ 62

  Fly    63 GRDHAGVFNYSRERAK---EMGTSYIE--YVFGKAIYNIIDADSAENVLNHPNLITK-------- 114
               |.|:...:.|..|   :|..:|.:  .|:...|...|       ||.||:.|..
Human    63 ---HLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFI-------VLCHPDTIRSITNASAAI 117

  Fly   115 ----GLVYNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL-----LQ 170
                .|...||.|:|..|:|.|.|.||...|:||||.||||||..:..||...:...|     |.
Human   118 APKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLA 182

  Fly   171 FEGQDEVTITLH------DVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRL 227
            .||...:.:..|      |.:.:  |:.:|.|:           |:...|.....::.....:|.
Human   183 SEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQ-----------ERPSEYIATILELSALVEKRS 236

  Fly   228 SNPLLWGDKLFEM-FAAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFA 291
            .:.|...|.|:.: ...:.|..|..:||.|:..:|.:||..|..:       ..||.|..|.:..
Human   237 QHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQ-------GIDDFFKDKAKSK 294

  Fly   292 MLD----TLIYAEKDG--LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEI 350
            .||    .|:..::||  |.|. .|..|.||.||.|:|||:.||.:.|.|::.:|:.||.|.||:
Human   295 TLDFIDVLLLSKDEDGKALSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEV 358

  Fly   351 QEHIDD-DLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIH 414
            ||.:.| |...::...|.:|.:|...:||:.||.|..|.:.|...|:..|.:|.::|||....|.
Human   359 QELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLID 423

  Fly   415 VFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQ 479
            :..:|.|...|..||.:.|.||.|||.:.|...|::|||||.|||||:.:||.|||.::.::|..
Human   424 IIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLH 488

  Fly   480 FKVLKAIDPQKIVFHTGITLRTQDKIRVKLVRR 512
            |:.|    |.          .|:.:.:::|:.|
Human   489 FRFL----PD----------HTEPRRKLELIMR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	148/492 (30%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	150/502 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850