DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	250/525 - (47%)	Gaps:	51/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAP-IAKGKTI---FGNTLDLYGR 64
            ||..|.....:|:|....:.|    ..|.:|....|.|:..:|. :.:.:.|   ||..||.:|
  Fly     6 LWCGLLFLLWIYFLWSRRRFY----LLTLKIPGPLGYPILGMAHWLMRREDILNAFGCFLDKHG- 65

  Fly    65 DHAGVFNYSRERAKEMGTSYIEYVFGKAIYNII-DADSAENVLNHPNLITKGLVYNFLHPFLRTG 128
              ..:|::                .|...:.|: |....:::...|:.:.||::|..:......|
  Fly    66 --PTIFSW----------------LGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVG 112

  Fly   129 LLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFEG-QDEVTITLHDVIPRFTLNS 192
            |.:....:|...||:|.|.|...:|..|..||..|:...|.|.|. ||:....|..::..|||..
  Fly   113 LFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGI 177

  Fly   193 ICETAMG--VKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAAKD--FASALDVV 253
            ..:|.||  || ||.:.:.:.....:..|.|.......:|.| ..:.....|.|:  :..|...:
  Fly   178 ATQTTMGSDVK-DEESFRSNSLLGRYQCILETMTDMCFSPWL-NSRFCRQLAGKESHYYQAKTEI 240

  Fly   254 HRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIGICEEVDTLM 318
            .:|..:||  .|.|.:||:....|...:|    |..|..|.|.:.  :.|:.....:.:|.:.::
  Fly   241 RQFIRKII--ERKLAEDEMGALPSIQSND----KNLFLNLVTDLM--RRGVFTLKNVEDESNIIV 297

  Fly   319 FEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHI----DDDLSNLDVGQLNKLKYLEYFMKET 379
            |..::||:..:.:.||.:::.|:.||..::||:...    |.|:|..|..|   :.||:..:.|:
  Fly   298 FGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQ---MVYLDLILNES 359

  Fly   380 TRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYW-DSPEEFRPERFLPENVQD 443
            .|:.|.||::.|:..|:.:|:||:::|||.||.|.::.:||:.|.| ...|.|.|:.|||.|:||
  Fly   360 MRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQD 424

  Fly   444 RHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGITLRTQDKIRVK 508
            :|.|||:||:.|.|||||.:||:...|..:..||:.::...:...:.:.|...||::.:....::
  Fly   425 KHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLE 489

  Fly   509 LVRRT 513
            |.:||
  Fly   490 LQKRT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	131/468 (28%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	131/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960