DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	441	Identity:	145/441 - (32%)
Similarity:	230/441 - (52%)	Gaps:	64/441 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VLN--HPNLITKGL---------VYNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQE 158
            |||  ||:.:...|         .|.|..|:|..|||.|||:||...|::|||.||:::|..:.:
Zfish    91 VLNIHHPSYVKTILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVK 155

  Fly   159 IFKTESQKFLL---QFEGQDEVTITLHDVIPRFTLNSICETAMGVKLDEMAEKG-DRYRENFSQI 219
            :. ::|.|.:|   :...:.|.:..|...:...||:||.:.|.....:...:.| :.|.:  :..
Zfish   156 LI-SDSTKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQ--AVF 217

  Fly   220 EECFIRRLSNPLLWGDKLFEMFAAKD------------FASALDVVHRFSSEIIAKRRDLLKDEL 272
            :.|.:..|.         |.:|....            |..|..:.|..::|:|.||:::||.|
Zfish   218 DLCHLVNLR---------FRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKME- 272

  Fly   273 DKSSSTADDDGFVSKKRFA-MLDTLIYA---EKDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGL 333
                   ::.|.|..:|:. .||.|:.|   .:.||.|. .|..||||.||||:|||:.|:.:..
Zfish   273 -------EEQGIVKNRRYLDFLDILLSARDEHQQGLSDE-DIRAEVDTFMFEGHDTTASGISWIF 329

  Fly   334 MNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETE 398
            .|::.||:.||.|.||||:.:|.. :.|:...|||:.|....:||:.||.|.||.:.|:..:...
Zfish   330 YNLACNPEHQEKCRQEIQQALDGK-ATLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPLT 393

  Fly   399 LANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKK 463
            ..:|..:|:|..|.:.::.||.|:..|::|.:|.|.|||||||.:|..:|:||||||.|||||:.
Zfish   394 FFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQN 458

  Fly   464 YAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHT-----GITLRTQDKIRVKL 509
            :||.|||..:.:.||::.::|  ||.    ||     .:.||:.:.|.:|:
Zfish   459 FAMNEMKVAVALTLKRYYLIK--DPD----HTPKMIPQVVLRSLNGIHIKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	144/439 (33%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	144/437 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850