Protein Alignment Cyp4p1 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 113/543 - (20%)
• Similarity: 222/543 - (40%)
• Gaps: 115/543 - (21%)

  Fly     6 LILALSALLYWLHRANKDY-HI------------LSFFTKRIRLKDGTPVEIIAPIAKGKTIFGN 57
            ::||......::|||...| ||            |.:|.|:.........::....||.   :|.
  Rat    12 VLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAKK---YGP 73

  Fly    58 TLDLYGRDHAGVFNYSRERAKE--MGTSY---------IEYVFGKAIYNIIDADSAENVLNHPNL 111
            .:.:.......|...|.|..|:  |.|.|         |:.|||:.::.
  Rat    74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFG---------------- 122

  Fly   112 ITKGLV----YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFH----FNILNQFQEIFKTESQKFL 168
              :|||    |.                :|:.:|:::...|.    .:::..|.|  |.|....:
  Rat   123 --QGLVSECDYG----------------RWYKQRRVMDLAFSRSSLVSLMGTFNE--KAEQLMEI 167

  Fly   169 LQFEGQDEVTITLHDVIPRFTLNSICETAMGVKLDEM--AEKGDRYRENFSQIEECFIRRLSNPL 231
            |:.:...:..:::.|::...|::.:.:.|.|::...:  |:|      ..||..:..:..:|..
  Rat   168 LEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQK------PLSQAVKVMLEGISAS- 225

  Fly   232 LWGDKLFEMFAAK-----DFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFA 291
              .:.|.:....|     :...::.::.:...:.:.:||:.||...|..:.
  Rat   226 --RNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDVPAD-------------- 274

  Fly   292 MLDTLIYAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD 356
            :|..::.||:....|.: :.:...|....|::|::..|.|.:|.:|..|:    ....:|..:|:
  Rat   275 ILTQILKAEEGAQDDEV-LLDNFVTFFIAGHETSANHLAFTVMELSRQPE----IVARLQAEVDE 334

  Fly   357 DLS---NLDVGQLNKLKYLEYFMKETTRLFPSVPIMGR-EAVQETELANGLILPKGAQITIHVFD 417
            .:.   :||...|.:|:||...:||:.||:|  |..|. ..::|..|.:|:.:|....:....:.
  Rat   335 VVGSKRHLDYEDLGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYV 397

  Fly   418 IHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKV 482
            :.|...|::.|..|.|:||.|...:.|.|  |.|||.|.|:|||:::|..|:|.:|..||::.:
  Rat   398 MGRMDTYFEDPLTFNPDRFGPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE- 459

  Fly   483 LKAIDPQKIVFHTGITLRTQDKI 505
            .:.:..|:.......||:..|.:
  Rat   460 FRLVPGQRFGLQEQATLKPLDPV 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	91/438 (21%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	102/494 (21%)