DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	391/514 - (76%)
Similarity:	447/514 - (86%)	Gaps:	2/514 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIILWLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRD 65
            |:||||:.|...|:.|::|.|:||.||.||.||||.|:|...|.|||:.||.|||.|:.||||:|
  Fly     1 MLILWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKD 65

  Fly    66 HAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGLL 130
            |:|||.:||:.||::|.||.||..|.||||:|||||||.|||.||||.||.:|:|||||||||||
  Fly    66 HSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTGLL 130

  Fly   131 TSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFEGQDEVTITLHDVIPRFTLNSICE 195
            ||||||||||||||:|||||||||||||||.|||.|||.||:|.||..|:|::||||||||||||
  Fly   131 TSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAIISLNEVIPRFTLNSICE 195

  Fly   196 TAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAAKDFASALDVVHRFSSEI 260
            |||||||||||||||||||||.|||||||||:||||||.|.||:|||.||:||||||||.|||||
  Fly   196 TAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAEKDYASALDVVHGFSSEI 260

  Fly   261 IAKRRDLLKDELDK--SSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIGICEEVDTLMFEGYD 323
            ||||||.|.||:|.  ::.||:|:.|.||||||||||||.|||||||||||||||||||||||||
  Fly   261 IAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYD 325

  Fly   324 TTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPI 388
            ||||||:||||||||.|::||.||||||.:|||:|:.|::|||||||.||||:|||.|||||||.
  Fly   326 TTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPA 390

  Fly   389 MGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFS 453
            ||||..:||||:||||||||:||.:||||||||.:|||||||||||||||||.|:||||||:|||
  Fly   391 MGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFS 455

  Fly   454 AGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGITLRTQDKIRVKLVRR 512
            ||||||||:|:||||||||||.|||||::|..|||:.|||.||:||||:::|.||||||
  Fly   456 AGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVKLVRR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	357/456 (78%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	355/450 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472667
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3BNNU
Homologene	1	1.000	-	-		H119658
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.900