Protein Alignment Cyp4p1 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 557
• Identity: 144/557 - (25%)
• Similarity: 247/557 - (44%)
• Gaps: 116/557 - (20%)

  Fly     1 MIILWLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRD 65
            :::|.:||.|      |:|.....|  ..|.|:     |.|    .|  |.....|..|:.|
Mouse    12 LVLLAIILVL------LYRYGTRTH--GLFKKQ-----GIP----GP--KPLPFLGTVLNYY--- 54

  Fly    66 HAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLR---- 126
             .|::.:..|       .|.:|  ||. :.:.|..:...|:..|..|...||.:.|..|..
Mouse    55 -TGIWKFDME-------CYEKY--GKT-WGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREF 108

  Fly   127 --TGLLT-----STGKKWHARRKMLTPTF-------HFNILNQFQEIFKTESQKFLLQFEGQDEV 177
              .|:::     |..::|...|.:|:|||       .|.::.|:.:|.    .|:|.| |.:..:
Mouse   109 GPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDIL----VKYLRQ-EAEKGM 168

  Fly   178 TITLHDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEEC--FIR-RLSNPLLWGDKLFE 239
            .:.:.||:..::::.|..|:.||.:|.:....|.:      :||.  |:| ...:|||:...||.
Mouse   169 PVAMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPF------VEEAKKFLRVDFFDPLLFSVVLFP 227

  Fly   240 MF---------------AAKDFASALDVVHRFSSEIIAKRR-DLLKDELDKSSSTADDDGFVSKK 288
            :.               :.:.|...:|.:.....:...|.| |.|:..::..:::.|.|   |.|
Mouse   228 LLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNSKDKD---SHK 289

  Fly   289 RFAMLDTLIYAEKDGLIDHIGICEEVDTLMF--EGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQ 351
            .|:.::.                 .|.:::|  .||:|||..|.|.|..::.:||.|    :::|
Mouse   290 AFSNMEI-----------------TVQSIIFISAGYETTSSTLSFTLYCLATHPDIQ----KKLQ 333

  Fly   352 EHIDDDLSNL---DVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITI 413
            ..||..|.|.   ....:.:::||:..:.||.||:|.|..:.|...::.|| ||:.:|||:.:.|
Mouse   334 AEIDKALPNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVEL-NGVYIPKGSMVMI 397

  Fly   414 HVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLK 478
            ..:.:|.:.::|..||||:||||..||......|.|:||..|.|||||.::|:..||..:..:|:
Mouse   398 PSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQ 462

  Fly   479 QFKVLKAID---PQKIVFHTGITLRTQDKIRVKLVRR 512
            .|......:   |.|: ...|| |:.:..|.:|:|.|
Mouse   463 NFSFQPCQETQIPLKL-SRQGI-LQPEKPIVLKVVPR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	122/464 (26%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	122/466 (26%)