DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	237/517 - (45%)
Similarity:	333/517 - (64%)	Gaps:	18/517 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLILALSALL---YW--LHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYG 63
            :|:.|..|:||   .|  |.:.||.|.||| ..||:|..||:|:|....:..|||.|||.|||..
  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILS-LCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLN 64

  Fly    64 RDHAGVFNYSRE-RAKEMGTSYI-EYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLR 126
            ...|.:|:|.|| .||..|.:|| .::|... |||:.|:.||.:.....:.||.:.|..:.|||.
  Fly    65 LTPANIFSYIRESTAKANGQNYIWNFLFAPE-YNIVRAEDAEEIFQSTKITTKNMSYELIRPFLG 128

  Fly   127 TGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFEGQDEVTITLHDVIPRFTLN 191
            .|||.|..:|||.|||.|||.||||||..|..|||.||:||:...:......:.|:.:||:||||
  Fly   129 DGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFELELNQIIPQFTLN 193

  Fly   192 SICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFA-AKDFASALDVVHR 255
            :|||||:|||||:|:| |:.||:.....|..|.:|:.|||::.:..|.:|. .|.::..|..:|.
  Fly   194 NICETALGVKLDDMSE-GNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILRTIHG 257

  Fly   256 FSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIGICEEVDTLMFE 320
            |||.||.::|...|.:     .....|.|..|:|:||||||:.||.:|.|||.|||:||:|.||.
  Fly   258 FSSGIIQRKRQQFKQK-----QLGQVDEFGKKQRYAMLDTLLAAEAEGKIDHQGICDEVNTFMFG 317

  Fly   321 GYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTRLFPS 385
            ||||||..|||.|:.::|:.|.||.||:|:|: :.:|:..:.:.|.|:|.:||..:||:.|||||
  Fly   318 GYDTTSTSLIFTLLLLALHADVQERCYEELQD-LPEDIDEVSMFQFNELIHLECVIKESLRLFPS 381

  Fly   386 VPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYV 450
            .||:||..::|: :.|||:|||.|||:||::||.|:|:::..|.:|.||||||||..:||.:|:|
  Fly   382 APIIGRTCIEES-VMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAFV 445

  Fly   451 PFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGITLRTQDKIRVKLVRR 512
            |||||.|||||:|:.:.|:|.|:..:::.||:|.|...:.:.|..||.||||..|:||...|
  Fly   446 PFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKFEAR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	212/457 (46%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	215/461 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472674
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3BNNU
Homologene	1	1.000	-	-		H119658
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.900