DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	134/552 - (24%)
Similarity:	212/552 - (38%)	Gaps:	97/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIILWLILALSALL----YWLHRANKDYHILSFFTKRIRLKDGTPVEIIAP-------IAKGKTI 54
            :::|.::|....||    .||      :.||.|:..| ||  |.|....||       :.:|...
  Fly    17 LVLLPVVLRGGCLLVVTIVWL------WQILHFWHWR-RL--GVPFVPAAPFVGNVWNLLRGACC 72

  Fly    55 FGNTL-DLYGRDHAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVY 118
            ||:.. :||         .|:|.|            |:|...|....:...:|..|.||.:.:|.
  Fly    73 FGDQFRELY---------ESKEAA------------GRAFVGIDVLHNHALLLRDPALIKRIMVE 116

  Fly   119 NFLH---------PFLRT----GLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQ 170
            :|..         |...|    .|..|..:.|....|:..|.|....:.....:.:...||....
  Fly   117 DFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEH 181

  Fly   171 FE----GQDEVTITLHDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPL 231
            .|    |:|.:.:.:..:...||.:.|...|.|::...:......:|....::.:...:||.:
  Fly   182 MEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLH-- 244

  Fly   232 LWGDKLFEMFAAKDFASALDVVHRFSSE---IIAKRRDLLKDELDKSSSTADD--DGFVSKKRFA 291
                 ||.||.....:..:. .|.:|.|   .:.|..|.:..:..:|.....|  |.|:..||..
  Fly   245 -----LFTMFFFPRLSHRVG-THLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTE 303

  Fly   292 MLDTLIYAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD 356
            ..:::|:...       ....:...|:..|:||:|..:.|.|..::.|...|:....|::..:..
  Fly   304 PAESIIHRPD-------FFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQS 361

  Fly   357 DLS-NLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQET--ELA--NG---LILPKGAQITI 413
            ... .|....:..|.||...:.|..||:|....:.|.....|  :|:  ||   ..|..|..:.|
  Fly   362 SQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYI 426

  Fly   414 HVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLK 478
            .|..|||:|:||.:||.|.||||..|..|..|...|:||.||.|.|||......|:|..::.:|.
  Fly   427 SVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILN 491

  Fly   479 QFKV--------LKAIDPQKIVF--HTGITLR 500
            .|:|        ....||:..|.  |.|..||
  Fly   492 HFRVEVCERTLPEMRFDPKAFVLTAHNGTYLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	117/488 (24%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	104/438 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010