DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	150/515 - (29%)
Similarity:	242/515 - (46%)	Gaps:	87/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDHAGV 69
            |:   |:.:|.|::         :|:....||:       ..|.....:.|...|.|...:..|:
  Rat    30 WI---LARILAWIY---------TFYDNCCRLR-------CFPQPPKPSWFWGHLTLMKNNEEGM 75

  Fly    70 FNYSRERAKEMGTSY--IEYVFGKAIYNIIDADSAENVLNHPNLITKGL------------VYNF 120
                 :....:|.::  |...:...:|.|:.       |.|||:|...|            :|.|
  Rat    76 -----QFIAHLGRNFRDIHLSWVGPVYPILR-------LVHPNVIAPLLQASAAVAPKEMTLYGF 128

  Fly   121 LHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTE-----------SQKFLLQFEGQ 174
            |.|:|..|||.|.|:||:..|::|||.|||:||..:.:||...           :.|...:.:..
  Rat   129 LKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLDMF 193

  Fly   175 DEVTITLHDVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKL 237
            :.:::...|.:.:  |:.:|.|:           |....|.....::....::|...|.|:.|.|
  Rat   194 EHISLMTLDSLQKCIFSFDSNCQ-----------ESNSEYIAAILELSSLIVKRQRQPFLYLDFL 247

  Fly   238 FEMFA-AKDFASALDVVHRFSSEIIAKRRDLLK----DELDKSSSTADDDGFVSKKRFAMLDTLI 297
            :.:.| .:.|..|.||||.|:..:|.:||..|.    ||..|:.:        ..|....:|.|:
  Rat   248 YYLTADGRRFRKACDVVHNFTDAVIRERRSTLNTQGVDEFLKARA--------KTKTLDFIDVLL 304

  Fly   298 YAEKD---GLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHI-DDDL 358
            .|:.:   ||.| :.|..|.||.||.|:|||:..|.:.|.|::.:|:.||.|.||::|.: |.:.
  Rat   305 LAKDEHGKGLSD-VDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREP 368

  Fly   359 SNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAK 423
            ..::...|.:|.:|...:||:.||.|.|.::.|...|:..|.:|.::|||....|.:|.:|.|..
  Rat   369 EEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPS 433

  Fly   424 YWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL 483
            .|..||.:.|.||.|||.|.|...|::|||||.|||||:.:||.|:|..:.:.|.:|.||
  Rat   434 VWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	142/466 (30%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	143/473 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850