Protein Alignment Cyp4p1 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 135/538 - (25%)
• Similarity: 243/538 - (45%)
• Gaps: 83/538 - (15%)

  Fly     5 WLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDHAGV 69
            |::||.|.:|::::....  |.|   .|::.:....||.:..      |||.     ||   .|:
  Rat    12 WVLLATSLMLFYIYGTYS--HGL---FKKLGIPGPKPVPLFG------TIFN-----YG---DGM 57

  Fly    70 FNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHP--NLITKGLVYNFLHPFLRTGLLTS 132
            :.:..:..|:.|..:..|...:....|:|.:..:.||...  ::.|....:..: .|::..:..|
  Rat    58 WKFDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPM-GFMKKAITMS 121

  Fly   133 TGKKWHARRKMLTPTFHFNILNQFQEIFKTESQ------KFLLQFEGQDEVTITLHDVIPRFTLN 191
            ..::|...|.:|:|||   ...:.:|:|....|      |.|.:.|.:.| .|.:.|:...::::
  Rat   122 EDEEWKRLRTILSPTF---TSGKLKEMFPLMRQYGDTLLKNLRREEAKGE-PINMKDIFGAYSMD 182

  Fly   192 SICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLF-------EMFAAKDF-AS 248
            .|..|:.||.:|.:....|.:.:...:|.:.   ::.:|.|....||       ||.....| ..
  Rat   183 VITGTSFGVNVDSLNNPQDPFVQKAKKILKF---QIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQ 244

  Fly   249 ALDVVHRFSSEIIAKRRDLLK----DELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIG 309
            :::...:|...:...|.|..:    |.|....:|.:..|..|:|..:.|:
  Rat   245 SMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLE--------------- 294

  Fly   310 ICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSN---LDVGQLNKLKY 371
            :..:....:|.|||.||..:.|.:..::..|:.|    :::|..||..|.|   :....|.:::|
  Rat   295 MAAQAIIFIFGGYDATSTSISFIMYELATRPNVQ----KKLQNEIDRALPNKAPVTYDALMEMEY 355

  Fly   372 LEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERF 436
            |:..:.|:.||:|....:.|.:.::.|: ||:.:|||..:||.::.:|||.:||..||||.||||
  Rat   356 LDMVVNESLRLYPIATRLDRVSKKDVEI-NGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERF 419

  Fly   437 LPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL---KAIDPQKI----VFH 494
            ..||......|.|:||..|.|||||.::|:..||..::.:|:.|.:.   |...|.||    :|
  Rat   420 SKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIF- 483

  Fly   495 TGITLRTQDKIRVKLVRR 512
                 :.:..|.:|||.|
  Rat   484 -----QPEGPIILKLVSR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	113/449 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	114/458 (25%)