DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	132/440 - (30%)
Similarity:	222/440 - (50%)	Gaps:	55/440 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 FGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNIL 153
            :.||:|:..|..:|:             ||:|...::..|||...|.||...||:|||.||:::|
  Rat    99 YAKAVYSRGDPKAAD-------------VYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVL 150

  Fly   154 NQFQEIFKTESQKFLLQFE--GQDEVTITLHDVIPRFTLNSICETAMGVKLDEMAEKGDR---YR 213
            ..:..||...::..|.::|  ..:..:..:...:....|:::.:...|        |||.   :|
  Rat   151 KPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFG--------KGDSGLGHR 207

  Fly   214 EN-----FSQIEECFIRRLSNPLLWGDKLFEMFA-AKDFASALDVVHRFSSEIIAKRRDLLKDEL 272
            :|     .|.:.....:|:.:.....|.::.:.. .:.|..|..:.|..:.|:|.:|:..|:||.
  Rat   208 DNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEK 272

  Fly   273 DKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIGI-------CEEVDTLMFEGYDTTSIGLI 330
            ::..       ...::....||.|:     |:.|..||       ..||||.||||:|||:.|:.
  Rat   273 ERKK-------IQQRRHLDFLDILL-----GVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGIS 325

  Fly   331 FGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQ 395
            :.|..|:|.|:.|:||.:|::..:.|. .:.....|.|:.||...|||..||:|.||.:.|:..:
  Rat   326 WFLYCMALYPEHQQLCREEVRGILGDQ-DSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNK 389

  Fly   396 ETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCI 460
            .....:|..||.|:.|::|::.:|||:..|..||.|.|.||.|||...||.:|::|||||.||||
  Rat   390 PVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCI 454

  Fly   461 GKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHT-GITLRTQDKIRVKL 509
            |:::||.|||.:..:.|.:|:.  ::||.|:.... .:.||:::.|.:.|
  Rat   455 GQQFAMNEMKVVTALCLLRFEF--SLDPSKMPIKVPQLILRSKNGIHLYL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	131/438 (30%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	131/436 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850