Protein Alignment Cyp4p1 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 139/547 - (25%)
• Similarity: 256/547 - (46%)
• Gaps: 104/547 - (19%)

  Fly     3 ILWLILALSALLY----------WLHRA--------------NKDYHILSFFTKRIRLKDGTPVE 43
            :|.::|.:|.||:          |:.||              :|:::.:..|....:|.:..|..
Human    15 LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCA 79

  Fly    44 IIAPIAKGK-TIFGNTLDLYGRDHAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLN 107
            :  |:..|. |:|                                      :::.|.|.|:.:|.
Human    80 V--PLWVGPFTMF--------------------------------------FSVHDPDYAKILLK 104

  Fly   108 HPNLITKGLV-YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQF 171
            ..:  .|..| :..|..::..||:|..|.||...|:::.|.|:.:||..|..:. :||.:.:|.
Human   105 RQD--PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMM-SESVRMMLN- 165

  Fly   172 EGQDEVT----ITLHDVIPRFTLNSICETAM----GVKLDEMAEKGDRYRENFSQIEECFIRRLS 228
            :.::.:.    :.|...:...||:||.:.|.    .::||...:...:...|.|:|..   :|::
Human   166 KWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISN---QRMN 227

  Fly   229 NPLLWGDKLFEMFAAKD--FASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFA 291
            |.|...|.:|: |:::.  |:.....:|:|:.::|..|::.|||:|.:.::        .|:|:.
Human   228 NFLHHNDLVFK-FSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTT--------QKRRWD 283

  Fly   292 MLDTLIYAEKDGLID--HIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHI 354
            .||.|:.|:.:...|  ...:..||.|.||.|:||||..:.:.|..::..|:.|:.|..||:|.:
Human   284 FLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348

  Fly   355 DDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIH 419
            .|. |::....|:::.|....:||..||:..|..:.|...:.....:|..||.|..:.|:::.:|
Human   349 GDG-SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALH 412

  Fly   420 RNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLK 484
            .|..:|:.|:.|.|.||..||.:..|.||::|||||.|||||:.:|:.|.|..:.:.|.:||:
Human   413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL-- 475

  Fly   485 AID----PQKIVFHTGITLRTQDKIRV 507
            |.|    ||.:   ..:.|::::.|.|
Human   476 APDHSRPPQPV---RQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	124/471 (26%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	131/515 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850