Protein Alignment Cyp4p1 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 139/547 - (25%)
• Similarity: 256/547 - (46%)
• Gaps: 104/547 - (19%)

  Fly     3 ILWLILALSALLY----------WLHRA--------------NKDYHILSFFTKRIRLKDGTPVE 43
            :|.::|.:|.||:          |:.||              :|:::.:..|....:|.:..|..
Human    15 LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCA 79

  Fly    44 IIAPIAKGK-TIFGNTLDLYGRDHAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLN 107
            :  |:..|. |:|                                      :::.|.|.|:.:|.
Human    80 V--PLWVGPFTMF--------------------------------------FSVHDPDYAKILLK 104

  Fly   108 HPNLITKGLV-YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQF 171
            ..:  .|..| :..|..::..||:|..|.||...|:::.|.|:.:||..|..:. :||.:.:|.
Human   105 RQD--PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMM-SESVRMMLN- 165

  Fly   172 EGQDEVT----ITLHDVIPRFTLNSICETAM----GVKLDEMAEKGDRYRENFSQIEECFIRRLS 228
            :.::.:.    :.|...:...||:||.:.|.    .::||...:...:...|.|:|..   :|::
Human   166 KWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISN---QRMN 227

  Fly   229 NPLLWGDKLFEMFAAKD--FASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFA 291
            |.|...|.:|: |:::.  |:.....:|:|:.::|..|::.|||:|.:.::        .|:|:.
Human   228 NFLHHNDLVFK-FSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTT--------QKRRWD 283

  Fly   292 MLDTLIYAEKDGLID--HIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHI 354
            .||.|:.|:.:...|  ...:..||.|.||.|:||||..:.:.|..::..|:.|:.|..||:|.:
Human   284 FLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348

  Fly   355 DDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIH 419
            .|. |::....|:::.|....:||..||:..|..:.|...:.....:|..||.|..:.|:::.:|
Human   349 GDG-SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALH 412

  Fly   420 RNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLK 484
            .|..:|:.|:.|.|.||..||.:..|.||::|||||.|||||:.:|:.|.|..:.:.|.:||:
Human   413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL-- 475

  Fly   485 AID----PQKIVFHTGITLRTQDKIRV 507
            |.|    ||.:   ..:.|::::.|.|
Human   476 APDHSRPPQPV---RQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	122/436 (28%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	130/496 (26%)