Protein Alignment Cyp4p1 and CYP19A1

DIOPT Version :9

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 111/480 - (23%)
• Similarity: 199/480 - (41%)
• Gaps: 123/480 - (25%)

  Fly    69 VFNYSRERAKEMGTSYIE---YVFGKAIYNIIDADSAENVLNHPNLITKGL-----VYNFLH-PF 124
            |:||.       |||.|.   |..|           ...:::|...:..|:     .||.:: .|
Human    38 VWNYE-------GTSSIPGPGYCMG-----------IGPLISHGRFLWMGIGSACNYYNRVYGEF 84

  Fly   125 LR-------TGLLTSTGKKWHARRKMLTPTFHFN-------------------ILNQFQEIFKTE 163
            :|       |.:::.:...:|..:..     |::                   |.|...|::||.
Human    85 MRVWISGEETLIISKSSSMFHIMKHN-----HYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTT 144

  Fly   164 SQKFLLQFEGQ--------------------DEVT-----ITLHDVIPRFTLNSICETAMGVKLD 203
            ...|:....|.                    :|||     :.:..::.|..|::.....:.:.||
Human   145 RPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLD 209

  Fly   204 EMA--EKGDRYRENFSQI---EECFIRRLSNPLLWGDKLFEMFAAKDFASALDVVHRFSSEIIAK 263
            |.|  .|...|.:.:..:   .:.|.:     :.|..|.:|. :.||...|::|:      |..|
Human   210 ESAIVVKIQGYFDAWQALLIKPDIFFK-----ISWLYKKYEK-SVKDLKDAIEVL------IAEK 262

  Fly   264 RRDLLKDE-LDKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHIGICEEVDTLMFEGYDTTSI 327
            ||.:..:| |::....|.:              ||.|||.|.:....:.:.:..::....||.|:
Human   263 RRRISTEEKLEECMDFATE--------------LILAEKRGDLTRENVNQCILEMLIAAPDTMSV 313

  Fly   328 GLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGRE 392
            .|.|.|..::.:|:.:|...:|||..|.:  .::.:..:.|||.:|.|:.|:.|..|.|.::.|:
Human   314 SLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRK 376

  Fly   393 AVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQR 457
            |: |.::.:|..:.||..|.:::..:|| .:::..|.||..|.| .:||..|:   :.||..|.|
Human   377 AL-EDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF-AKNVPYRY---FQPFGFGPR 435

  Fly   458 NCIGKKYAMQEMKTLMVVLLKQFKV 482
            .|.||..||..||.::|.||::|.|
Human   436 GCAGKYIAMVMMKAILVTLLRRFHV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	111/480 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	100/428 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040