DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	545	Identity:	162/545 - (29%)
Similarity:	255/545 - (46%)	Gaps:	87/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLIL-------ALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLY 62
            ||:|       .|:.:|.|.:..   ||            :|..:.......|.....|
Human    19 WLLLLVVGASWLLARILAWTYAF---YH------------NGRRLRCFPQPRKQNWFLG------ 62

  Fly    63 GRDHAGVFNYSRERAKEMGTSYIEYVFG--------KAIYNIIDADSAENVLNHPNLIT-KGLV- 117
               |.|:...:.|..:.:......|..|        ..|.|:...|...:|:|..:.|| |.:|
Human    63 ---HLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVF 124

  Fly   118 YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL------LQFEGQ-- 174
            |..|.|:|..|||.|.|.||...|::|||.||||||..:.:|| ::|...:      |..||.
Human   125 YKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIF-SKSANIMHAKWQRLAMEGSTC 188

  Fly   175 ----DEVTITLHDVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLW 233
                :.:::...|.:.:  |:.:|.|:           ||...|.....::....::|.:....:
Human   189 LDVFEHISLMTLDSLQKCIFSFDSNCQ-----------EKPSEYITAIMELSALVVKRNNQFFRY 242

  Fly   234 GDKLFEMF-AAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSK---KRFAMLD 294
            .|.|:.:. ..:.|..|..:||.|:..:|.:||..|       :|...||...:|   |....:|
Human   243 KDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTL-------TSQGVDDFLQAKAKSKTLDFID 300

  Fly   295 TLIYAE-KDG--LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD 356
            .|:.:| |:|  |.|. .|..|.||.||.|:|||:.||.:.|.|::.:|:.||.|.||:||.:.|
Human   301 VLLLSEDKNGKELSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364

  Fly   357 -DLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHR 420
             :...::...|.:|.:|...:||:.||.|.:|...|...|:..|.:..::|||....|::|.||.
Human   365 REPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHH 429

  Fly   421 NAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL-K 484
            |...|..||.:.|.||.|||.|.|...|::|||||.|||||:|:||.|||.::.:.|.:|::| .
Human   430 NPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD 494

  Fly   485 AIDPQKIVFHTGITLRTQDKIRVKL 509
            ..:|::.   ..|.||.:|.:.:::
Human   495 HREPRRT---PEIVLRAEDGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	152/487 (31%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	149/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850