Protein Alignment Cyp4p1 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 162/545 - (29%)
• Similarity: 255/545 - (46%)
• Gaps: 87/545 - (15%)

  Fly     5 WLIL-------ALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLY 62
            ||:|       .|:.:|.|.:..   ||            :|..:.......|.....|
Human    19 WLLLLVVGASWLLARILAWTYAF---YH------------NGRRLRCFPQPRKQNWFLG------ 62

  Fly    63 GRDHAGVFNYSRERAKEMGTSYIEYVFG--------KAIYNIIDADSAENVLNHPNLIT-KGLV- 117
               |.|:...:.|..:.:......|..|        ..|.|:...|...:|:|..:.|| |.:|
Human    63 ---HLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVF 124

  Fly   118 YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL------LQFEGQ-- 174
            |..|.|:|..|||.|.|.||...|::|||.||||||..:.:|| ::|...:      |..||.
Human   125 YKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIF-SKSANIMHAKWQRLAMEGSTC 188

  Fly   175 ----DEVTITLHDVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLW 233
                :.:::...|.:.:  |:.:|.|:           ||...|.....::....::|.:....:
Human   189 LDVFEHISLMTLDSLQKCIFSFDSNCQ-----------EKPSEYITAIMELSALVVKRNNQFFRY 242

  Fly   234 GDKLFEMF-AAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSK---KRFAMLD 294
            .|.|:.:. ..:.|..|..:||.|:..:|.:||..|       :|...||...:|   |....:|
Human   243 KDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTL-------TSQGVDDFLQAKAKSKTLDFID 300

  Fly   295 TLIYAE-KDG--LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD 356
            .|:.:| |:|  |.|. .|..|.||.||.|:|||:.||.:.|.|::.:|:.||.|.||:||.:.|
Human   301 VLLLSEDKNGKELSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364

  Fly   357 -DLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHR 420
             :...::...|.:|.:|...:||:.||.|.:|...|...|:..|.:..::|||....|::|.||.
Human   365 REPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHH 429

  Fly   421 NAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL-K 484
            |...|..||.:.|.||.|||.|.|...|::|||||.|||||:|:||.|||.::.:.|.:|::| .
Human   430 NPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD 494

  Fly   485 AIDPQKIVFHTGITLRTQDKIRVKL 509
            ..:|::.   ..|.||.:|.:.:::
Human   495 HREPRRT---PEIVLRAEDGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	148/452 (33%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	148/463 (32%)