DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	534	Identity:	182/534 - (34%)
Similarity:	271/534 - (50%)	Gaps:	36/534 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIILWLILALSALLYW-------LHRANKDYHILSFFTKRIR-LKDGTPVEIIAPIAKGKTIFGN 57
            |:.|||.|:...||.|       |..|.   .::|.|...:. .:....:..|..:|:...:.|:
Mouse     1 MLWLWLGLSGQKLLLWGAASAVSLAGAT---ILISIFPMLVSYARKWQQMRSIPSVARAYPLVGH 62

  Fly    58 TLDLYGR-DHAGVFN---YSRERAKEMGTSYIEYVFGK----AIYNIIDADSAENVLNHPNLITK 114
            .  ||.: ::|..|.   |..|..:.:  ..|:...|.    |:|.   |::.|.:|.....|.|
Mouse    63 A--LYMKPNNAEFFQQLIYYTEEFRHL--PIIKLWIGPVPLVALYK---AENVEVILTSSKQIDK 120

  Fly   115 GLVYNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFEGQ-DEVT 178
            ..:|.||.|:|..|||||||.||..|||||||||||.||..|.::...::...:.:.|.. ::..
Mouse   121 SFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEA 185

  Fly   179 ITLHDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMF-A 242
            ......|....|:.|||||||..:...:.....|.....::.:...||:..|.||.|..:.:| .
Mouse   186 FNCFFYITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKE 250

  Fly   243 AKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFV--SKKRFAMLDTLIYA--EKDG 303
            .:|....|..:|.|::.:||:|   :|:...:...|....|.:  ..||.|.||.|:..  |:..
Mouse   251 GRDHKRGLKCLHTFTNNVIAER---VKERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGN 312

  Fly   304 LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNK 368
            .:....|.|||||.||||:|||:..:.:.|..:..||:.|....||:.|........:.:..|.|
Mouse   313 RLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKK 377

  Fly   369 LKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRP 433
            ||||:..:|||.|:|||||:..|...::.|: .|..:.||.:..|..:.:||:.:|:..||||||
Mouse   378 LKYLDCVIKETLRVFPSVPLFARSLSEDCEV-GGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRP 441

  Fly   434 ERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGIT 498
            |||.|||.|.||.|||||||||.|||||:|:|:.|.||::..:|:||.|......:::.....:.
Mouse   442 ERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLI 506

  Fly   499 LRTQDKIRVKLVRR 512
            ||..:.|.:||.||
Mouse   507 LRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	164/468 (35%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	165/476 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950