DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	514	Identity:	136/514 - (26%)
Similarity:	229/514 - (44%)	Gaps:	99/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDHAGV 69
            |::||:  :|..|:|.....|  ..|.|:     |.|    .|  |.....|..|:.|    .|:
Mouse    12 WVLLAI--ILVLLYRYGTRTH--GLFKKQ-----GIP----GP--KPLPFLGTVLNYY----KGL 57

  Fly    70 FNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLR------TG 128
            :.:..|       .|.:|  ||. :.:.|......|:..|.:|...||......|..      .|
Mouse    58 WKFDME-------CYEKY--GKT-WGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVG 112

  Fly   129 LLT-----STGKKWHARRKMLTPTF-------HFNILNQFQEIFKTESQKFLLQFEGQDEVTITL 181
            :::     |..::|...|.:|:|||       .|.::.|:.:|.    .|:|:| |.:....:|:
Mouse   113 IMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDIL----VKYLMQ-EAEKGKPVTM 172

  Fly   182 HDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIR-RLSNPLLWGDKLFE------ 239
            .||:..::::.|..|:.||.:|.:....|.:.|....|    :| ...:||::...||.
Mouse   173 KDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGI----LRVDFFDPLVFSVVLFPFLTPVY 233

  Fly   240 ------MFAAKDFASALDVVHRF-SSEIIAKRR---DLLKDELDKSSSTADDDGFVSKKRFAMLD 294
                  ||...........|:|. .|.:.:|::   |.|:..::..:::.|.|   |.|  |:.|
Mouse   234 EMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKD---SHK--ALSD 293

  Fly   295 TLIYAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLS 359
            ..|.|:.             ...:|.||:|||..|.|.|..::.:||.|    :::||.||:.|.
Mouse   294 MEITAQS-------------IVFIFAGYETTSSTLSFTLYCLATHPDIQ----KKLQEEIDETLP 341

  Fly   360 NL---DVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRN 421
            |.   ....:.:::||:..:.||.||:|....:.|...::.|| ||:.:|||:.:.|..:.:|.:
Mouse   342 NKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVEL-NGVYIPKGSTVMIPSYALHHD 405

  Fly   422 AKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQF 480
            .::|..||||:||||..||......|.|:||..|.|||||.::|...||..:..:::.|
Mouse   406 PQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNF 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	123/465 (26%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	126/478 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910