DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p1 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	474	Identity:	130/474 - (27%)
Similarity:	221/474 - (46%)	Gaps:	60/474 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HAGVFNYSRERAKEMGTSYIEY-----VFGKAIYNIIDADSAENVLNHPNLITKGLV-------- 117
            |.|:..::.|..:.:.....:|     .|....||::.       |.||:.|...|.
Zfish    48 HMGLMGHNEEGLQRVDDLVCKYGHSCSWFLGPFYNMVR-------LFHPDYIRSLLTASASITLK 105

  Fly   118 ----YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFE-----G 173
                |.|:.|:|...||..:|::|...|::|||.|||:||.::..||...:.  ::..|     .
Zfish   106 DRIFYGFMKPWLGNCLLLQSGQEWSRHRRLLTPAFHFDILKKYVHIFNQSTN--IMHDEWRRLLA 168

  Fly   174 QDEVTITLHDVIPRFTLNSI------CETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSN-PL 231
            :.|.::.:.:.|...||:|:      |:|       ...||..:|......:....::|... |.
Zfish   169 KGEHSVDMFEQISSLTLDSLLKCTFSCDT-------HSQEKPRQYISAILDLSRLLVQRQHYLPY 226

  Fly   232 LWGDKLFEMFAAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTL 296
            .|....:.....:.|..|..|||:|:::|:.:||..|..:.|..|...:...:..:|...::|.|
Zfish   227 HWDWLYWRSAQGRRFQQACAVVHQFTADIVQERRTQLDQQSDPESHPENTGRYRKRKNTDLIDLL 291

  Fly   297 IYAEKD---GLIDHIGICEEV----DTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHI 354
            :.|:.|   ||.:     ||:    |..||.|:|||:..|.:...|:::|.|.||.|..|:::.:
Zfish   292 LLAKDDKGEGLTN-----EEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLL 351

  Fly   355 -DDDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDI 418
             |.|...:....|::|.:....:||:.||...|..:.|...|..:.....::|.|....|.::.:
Zfish   352 ADRDTHTIGWEDLSQLTFTTMCIKESLRLHSPVLALTRYYSQNMKTPGDCVIPHGCLCLISIYGV 416

  Fly   419 HRNAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL 483
            |||.:.|..|..|.|.||.|.|...|..:|::|||||.|||||:.:||.|||.::.:.|.:||:|
Zfish   417 HRNPQVWPDPLVFDPTRFDPHNSDSRSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKIL 481

  Fly   484 KAIDPQKIVFHTGITLRTQ 502
            ....|.:.::.  :.||.:
Zfish   482 PGPKPVRRLYQ--LVLRAE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	130/474 (27%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	130/474 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010