DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTRR and Nos

DIOPT Version :9

Sequence 1:	NP_001351369.1	Gene:	MTRR / 4552	HGNCID:	7473	Length:	698	Species:	Homo sapiens
Sequence 2:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	203/755 - (26%)
Similarity:	316/755 - (41%)	Gaps:	166/755 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     6 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTAR 70
            :||||:.|:::..|:::|| .:.|.|:|.::|:|:.|...::.| |.|:||.||.|.||||:...
  Fly   673 VLYATETGKSEQYAKQLCE-LLGHAFNAQIYCMSDYDISSIEHE-ALLIVVASTFGNGDPPENGE 735

Human    71 KFVKEI-------------------------------QNQTLPV-----------------DFF- 86
            .|.:|:                               :...||:                 |.|
  Fly   736 LFSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFT 800

Human    87 -------AHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIA 144
                   :::|:.:..||.|.|..||..|:.:|..|.|||........:.|:..|.|.....|
  Fly   801 EETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKW-- 863

Human   145 GLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQ 209
                                      :|          |:..:..:...|..::|....|..|:.
  Fly   864 --------------------------AP----------EVFKLACETFCLDPEESLSDASLALQN 892

Human   210 NAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQ-EESQVSVTSADPV 273
            :::..|            ..|.||..::.||:              .||.: ...:|....|.
  Fly   893 DSLTVN------------TVRLVPSANKGSLD--------------SSLSKYHNKKVHCCKAK-- 929

Human   274 FQVPISKAVQLT-TNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKR 337
                 :|...|| .::..|||:|  |:|......|:|||...:...|....|..||.||...|..
  Fly   930 -----AKPHNLTRLSEGAKTTML--LEICAPGLEYEPGDHVGIFPANRTELVDGLLNRLVGVDNP 987

Human   338 EHCVLLKIKADTKKKGATLP-----QHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAE 397
            :..:.|::..:.:.......     ..||.. :|:.:.....::...|.:..|..|..:..|:|:
  Fly   988 DEVLQLQLLKEKQTSNGIFKCWEPHDKIPPD-TLRNLLARFFDLTTPPSRQLLTLLAGFCEDTAD 1051

Human   398 KRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFH 462
            |.||:.|.:...|.:..|..|  ...|||:|..||||:||..|||..|..||||.||.:||....
  Fly  1052 KERLELLVNDSSAYEDWRHWR--LPHLLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRV 1114

Human   463 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT 527
            ..::|....||::.........|.|||:.:|                  ||.....::.:..|:.
  Fly  1115 SDEIHLTVAIVKYRCEDGQGDERYGVCSNYL------------------SGLRADDELFMFVRSA 1161

Human   528 NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKE 592
            ..||||.|.|.|||::|||||||||..|.|..:.|.:..|......||||||||::|.| |:.:|
  Fly  1162 LGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVD-LYAEE 1225

Human   593 LRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMA 657
            .....|..||..:.::.||     |:..|..||||.|:.....:.::::||.||||||||. .||
  Fly  1226 KAELQKDQILDRVFLALSR-----EQAIPKTYVQDLIEQEFDSLYQLIVQERGHIYVCGDV-TMA 1284

Human   658 KDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIW 697
            :.|:..:.:.|:.:....:.|....|.||::|.||.:||:
  Fly  1285 EHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHEDIF 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTRR	NP_001351369.1	Flavodoxin_1	6..142	CDD:306716	48/191 (25%)
		Hinge	166..247		12/80 (15%)
		methionine_synthase_red	277..697	CDD:99800	137/425 (32%)
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	201/752 (27%)
		Flavodoxin_1	673..863	CDD:278677	48/191 (25%)
		Nitric_oxide_synthase	931..1328	CDD:99799	138/424 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910