Protein Alignment MTTP and mttp

DIOPT Version :10

• Sequence 1: NP_000244.2
• Gene: MTTP / 4547
• HGNCID: 7467
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_998135.3
• Gene: mttp / 406207
• ZFINID: ZDB-GENE-040419-2
• Length: 884
• Species: Danio rerio
• Alignment Length: 884
• Identity: 485/884 - (54%)
• Similarity: 646/884 - (73%)
• Gaps: 2/884 - (0%)

Human     1 MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDV 65
            |:.:|.|.||..:....|..|  .|..|:|.:||:.:|||||.|:|..|..:.:||:||||:||:
Zfish     1 MMPVAGLLLCVTAVLCTSALG--AGPRLDNGKLYRYSYSTEVGLNRPTGSPEGNVGFRISSDVDI 63

Human    66 ALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHG 130
            .|.||||:..|:||:|:.:.::.||:..:...:.:||.|.|...|:||..|||||||.|:....|
Zfish    64 NLAWRNPEIQDEQLLQVQISNIQVESAGKHSRKNNIFHGSSAESILGKVRLEALQRPFLVLWKMG 128

Human   131 KVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCK 195
            |::..|:.:.|...::|:|||:||:...||.||..:|.|.||.|.|.|:.::.:||:.|.|::||
Zfish   129 KIRSLYAQKAEPATVKNLKRGVASMLMMQLKSGKMSEADASGKCLVEYKVNKHQVIRTKHLETCK 193

Human   196 IARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKT 260
            ...:||||.:.|||:|.|..:.|...:|:..:.:..|:|||...:|.......|::|:|.|.||.
Zfish   194 SQETGFTTHSPVLGISGKCAAETVITLENGIIKSADAKETHVLSINARHKAATKVLSRQSLTLKA 258

Human   261 TEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEA 325
            .||||..::||..|.::||:|.|:.::.::.:..:..|||||:|.|.|::.|..|:|::||||||
Zfish   259 IEAGPAEVAGKDVAGVVKALDDKFLSVGVIVEKTKPKCKGCPNLMETWKAVRSQLEPNSLSKAEA 323

Human   326 VRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQ 390
            .|:||..:..||.:.|.|||.:|:..:|..|||||||||||||..||.|||:||||.....:|||
Zfish   324 PRSFLTLVHSLRKSSKSEILTVLQNCSKTALPQLVDAVTSAQTPSSLSAILEFLDFSKKDGLILQ 388

Human   391 ERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKK 455
            |||||||||||||.|.:|::|:...:|.|||::|:|:|:||.|.|:||||....|.|.||::.|:
Zfish   389 ERFLYACGFASHPTESMLQSLLEVSQGKIGSTEIKESVVIIMGALLRKLCLKGACDLPAVLKVKE 453

Human   456 LILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEV 520
            |:|.|.:..:::.:.:||||||||||||||||.|.||||:..|..|.:|.|||||||...||.||
Zfish   454 LLLAGPDSTQEESEVQMYLLALKNALLPEGIPVLAKYAESEVGAYSTIAITALQRYDPALITAEV 518

Human   521 KKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRF 585
            ||.||||||||::::||.||.|||.:|:::|||||:|||:|||||.||.|||||||:.:||:|||
Zfish   519 KKALNRIYHQNQRIYEKNVRAAAADVIMSSNPSYMEVKNLLLSIGHLPHEMNKYMLSKIQDVLRF 583

Human   586 EMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNI 650
            :|||.|:||:|:|:|::|||||||::||||||:|::..:.....||:|||||||||:|||||:||
Zfish   584 QMPAYKLVRQVMKDMISHNYDRFSKTGSSSAYSGFMAETVDVTCTYNLDILYSGSGVLRRSNMNI 648

Human   651 FQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMS 715
            :.....|.|||.||.|||||||:|||||||||||.|:|:|||||:||||||||||||.|||||||
Zfish   649 YGQSNNALLHGLQVTIEAQGLESLIAATPDEGEEELESFAGMSALLFDVQLRPVTFFKGYSDLMS 713

Human   716 KMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN 780
            ||.|.|||||:||||||||.||||.:.|||||:|:.|.|.||:|||||.||||||||||||.|.|
Zfish   714 KMFSMSGDPINVVKGLILLTDHSQVIPLQSGLRASAEFQAGLSIDISGGMEFSLWYRESKTSVNN 778

Human   781 RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYE 845
            |..:||..::|||:.||.||:|...||||.|:||:|||||:|||||||||||...|||:...|.|
Zfish   779 RGALVIIGNMTVDTDFVSAGVEVGFETEATLDFITTVQFSEYPFLVCMQMDKTTFPFRETVSKQE 843

Human   846 RLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAP 884
            :|.||:.:..::.::.|:.|.|||||||||.|||.||.|
Zfish   844 KLPTGQTFSRKRSRDQVVPGSEFPLHQENSNMCKKVFEP 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTTP	NP_000244.2	Vitellogenin_N	28..584	CDD:460170	275/555 (50%)
		MTP_lip_bd	592..886	CDD:466086	195/293 (67%)
mttp	NP_998135.3	None