Protein Alignment MTTP and dsc-4

DIOPT Version :10

• Sequence 1: NP_000244.2
• Gene: MTTP / 4547
• HGNCID: 7467
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_499903.3
• Gene: dsc-4 / 176852
• WormBaseID: WBGene00001099
• Length: 892
• Species: Caenorhabditis elegans
• Alignment Length: 968
• Identity: 188/968 - (19%)
• Similarity: 348/968 - (35%)
• Gaps: 249/968 - (25%)

Human    29 NNDRLYKLTY---STEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVE 90
            |..||.|:.|   :..::.|....|.:|. ...|:.|.....|..:.:|  ..|.:.|:...|.:
 Worm    47 NTVRLLKVDYWFRTESMIYDDIDNKEKDP-STVIAGNFSFETLHHDVEG--GMLGRFTLTQCNTD 108

Human    91 NVNQQRGEKSIFKGKSPSKI-----MGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKR 150
            |..            :||.|     .|..|.|        |::..        .:|:.|..|...
 Worm   109 NCG------------NPSPIYIAFRQGGNNAE--------HILKA--------SDESDATWNFLY 145

Human   151 GLASLFQTQLSSGTTNE--VD-ISGNCKVTYQAHQDKVIKIKALDSCKIARSGF-TTPNQVLGVS 211
            .:.:...|....|..:|  || |.|.|.|.:...:||..: :.::.|.:   |: |...:..|:.
 Worm   146 AIVNTIYTPAEYGEGDEQTVDTIYGRCFVNFGRPEDKRFR-RIIEKCDL---GYGTNFTKFEGIE 206

Human   212 SKATSVTTYKIE----DSFVIAVLAEET--------HNFGLNFLQTIKGKIVSKQKLELKT--TE 262
            |.......:..:    |:.:|.|.|.|.        ..:|.........:|.::.::.:.:  .:
 Worm   207 SVQYDQDVWYTQNTKVDADIIMVDAIEMLAFKSPLHEKYGFTLESRTHVEITNRTRVFVTSYCND 271

Human   263 AGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVR 327
            ..|.....:||...::.....|..:.|..:  ||:     .|::|..:.|::||....|......
 Worm   272 TVPSAKCAEQAFGAVRVGGKLYEHVKIAQE--QSN-----KLTKLIGTYRRHLQDMGDSHICEKH 329

Human   328 NFL--AFIQHLRTAKKEEILQILKM-ENKEVLPQLVDAVTSAQTSDSL----EAIL----DFLDF 381
            :.|  ...|..|.||:::....::. ||..||..:..|:....|::|:    |.:|    |:||
 Worm   330 SLLYSQIAQEARLAKRQDWEAAIQYPENDHVLSLIASALGGVGTAESITTAREVLLTASPDYLD- 393

Human   382 KSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSD-----IRETVMIITGTLVRKLCQ 441
                      ..|:....:|..||:..:.|: .:.||:....     :..|:    .|::.|.|:
 Worm   394 ----------DLLFGISQSSSNNEKWHKQLM-YWLGSLDKKSEEYWKVANTI----ATVLNKRCE 443

Human   442 NEGCKLKAVVEAKKLIL---------GGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGE 497
            .....|.:..:.|:.|:         ||:|              ::...:.|.||....|
 Worm   444 ASTSSLNSCNKGKETIVNKFITDLTAGGVE--------------VRVLEVLENIPIFGSY----- 489

Human   498 GPISHLATTALQRYDLPFITDEVKK-TLNRIYHQNRKVHE--------KTVRTA----------- 542
                    |..:::.....:::|:| .||.|...::.::|        |..|..
 Worm   490 --------TFAKKFICETESEDVQKAALNVILAASKNLYETQLTHKLIKLFRNTCSQETPTSHSQ 546

Human   543 -AAAIILNNNPSYMDVKNILLSIGEL-PQEMNK--YMLAIVQ-----DILRFE----MPASKIVR 594
             |..|:|...|.:.:|..::|....| |.:..|  |:...::     |.|:.|    |...|:.|
 Worm   547 LAIDILLKCVPDHQNVATLILRTETLNPDDQEKWHYLYKAIEASGNKDELKAEFWSRMRKFKVFR 611

Human   595 -----RVL--------KEMV-AHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRR 645
                 |.|        :|:. |.|:..|     |:|.|.::::|.: .|.:.|.:...      |
 Worm   612 PNFLHRALQADSHVHWQEIADASNFQLF-----STANTEFLQKSFK-RSIFELSMKKG------R 664

Human   646 SNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDV---QLRPVTFF 707
            ...|:|           .:.|:.:.||..:.     |..:..|.|...::...|   :|.....|
 Worm   665 KEHNLF-----------SLSIDTEHLEQFVT-----GSASSRSGAPQGSVRIGVAGHKLPTHHIF 713

Human   708 NGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYR 772
            .|.:||:|.:..|.|......:|.:.:.|....:.|.|||..:::..|.:::.:..:.|.|||.:
 Worm   714 KGSTDLLSTVWEADGRTHKAFEGHVPVRDVRLSVPLLSGLTLDVDSVGAISMRVLASAEVSLWNQ 778

Human   773 ESKTRVKNRVTVVITTDITVDSSFVKAGL----ETSTETEAGLEFISTVQ------FSQYPFLVC 827
            .|..:.:         ..|..|..:.|.|    |.....|:.:..:||..      |...|:..|
 Worm   779 RSNAKAE---------AYTSGSLHLTASLYHHSEPVRHVESTISALSTFTTDTRAIFETLPYDFC 834

Human   828 MQMDKDEAPFRQ----------FEKK---YERLSTGRGYVSQKRKESVLAGCEFPLHQ 872
            ::.........|          .:||   .:|:..|   |:.:..:|.:..|...|.|
 Worm   835 LRTSNSNVDINQKTVVQDQIGKHKKKTLNRKRVHPG---VTYRLDDSTIRQCNSYLEQ 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTTP	NP_000244.2	Vitellogenin_N	28..584	CDD:460170	120/634 (19%)
		MTP_lip_bd	592..886	CDD:466086	64/321 (20%)
dsc-4	NP_499903.3	Vit_open_b-sht	<713..889	CDD:472237	39/187 (21%)