Protein Alignment mtd and TBC1D10A

DIOPT Version :9

• Sequence 1: NP_001246928.1
• Gene: mtd / 45467
• FlyBaseID: FBgn0013576
• Length: 1344
• Species: Drosophila melanogaster
• Sequence 2: NP_001191169.1
• Gene: TBC1D10A / 83874
• HGNCID: 23609
• Length: 515
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 101/541 - (18%)
• Similarity: 163/541 - (30%)
• Gaps: 180/541 - (33%)

  Fly   375 AKDDASSSSTHDADGASLSGKSSPVERKLSGDESREKDILEGLRPGSPKPGHIER-------VGG 432
            ||.:..:.....|.|.||||..   |....|.::...|.|..|...|...|..||       :.|
Human     2 AKSNGENGPRAPAAGESLSGTR---ESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVG 63

  Fly   433 SSQQQQA-----------------EEEANKSD-----DPVITQRFLKINVRHITDG--------- 466
            |...:.|                 :.|:...|     |..:.::..||.:| ...|
Human    64 SQGAEGAPCPLLHRLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLR-CQKGIPPSLRGRA 127

  Fly   467 -QGVVGGVLLVTPNAVMFDP---NVSDPLVIEHGPESYGVIAPMELVVNAAI-----FHDIAHMR 522
             |.:.||.:.:..|...||.   :..||..::              |:...:     ||::...|
Human   128 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLD--------------VIERDLHRQFPFHEMFVSR 178

  Fly   523 VAGGAGQG-----LNSASGDAEKPEIYY---PKPV----------------LVEEDSKELPEQQS 563
              ||.||.     |.:.:  ..:||..|   ..|:                ||:...|.||...|
Human   179 --GGHGQQDLFRVLKAYT--LYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYS 239

  Fly   564 LLGEDGNKRLDAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVE------------------ 610
                   ::|:|      |..|.|.|.|...:......|...|::::
Human   240 -------EKLEA------IQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLP 291

  Fly   611 -DSSMEAKDSAKTD---------------ALDDEDK-KAGLGLSSTRSTLEERRKSLLDHHWAI- 657
             .|.:...|....:               ||...:| ||..|...|...|......::...:.:
Human   292 WSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQ 356

  Fly   658 -----PSKDRSSEDE--------GDNESNVTVDSGARVQDPHSANSSVSGV----PLSQPPVAAA 705
                 |..:|..|.|        .:....:...|..|:   |.|.:.:...    |..||..:..
Human   357 EVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRL---HGAKAILDAEPGPRPALQPSPSIR 418

  Fly   706 AAAAAVAPASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREPVPNVQPIPKKTVYSDADIVLSS 770
            ....|..|.|...|.||.....|..:|:..:...:     :.|.||...:          :..:.
Human   419 LPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLE-----KPPAPNQAMV----------VAAAG 468

  Fly   771 DWVPPKTIVPTHFSESPPRST 791
            |..||:.:.|   .:|.|:.:
Human   469 DACPPQHVPP---KDSAPKDS 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		13/46 (28%)
		TBC	117..320	CDD:214540	39/233 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..515		20/102 (20%)
		ZipA	<403..>502	CDD:331990	20/102 (20%)
		Binding to the PDZ domain of EBP50	512..515

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910