DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtd and tbc1d24.1

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_012826017.1	Gene:	tbc1d24.1 / 780158	XenbaseID:	XB-GENE-981681	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	116/565 - (20%)
Similarity:	200/565 - (35%)	Gaps:	181/565 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   896 VFSKVFSSSPITLVS-------ELGGNLFSKTPSEDSGGSPVP------PLTPHSTHSEGHMTYG 947
            |:.|:....|...|:       ::.|.:..|.|   :...|:|      .:..:..:|||
Frog    54 VYQKLIKEIPCRTVTPDASVYRDIVGKIVGKRP---ASSLPLPEFVDDRQIPSYCLNSEG----- 110

  Fly   948 RSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSM-----DDKPELFISVDKLIPRPARAC 1007
               ||. :|...   |..|.:..:....|.|.  |:|::     .|:.|.|.:|.:::     ||
Frog   111 ---IGA-VRKII---TCISNQFPDISFCPALP--SLVALLLHYSQDEAECFENVSRIL-----AC 161

  Fly  1008 LDPPLYLRLRMGKPIGKA-IPLPTSVMSYGKNKLRAEYWFSVPKNRV---DELYRFINTWVKHLY 1068
            .||...|       :.:. :...:|.|::|  .|..:|.....|..|   :::....:.|.:.::
Frog   162 NDPNRRL-------VDQTFLAFESSCMTFG--DLAGKYCQGPHKLMVAVSEDVLEVYSDWQRWIF 217

  Fly  1069 GELDEEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRESWELIKAPFAKTYKIIK 1133
            |||....| .|.|::.                   ..:|.::  |.|.:..|:|. |.|......
Frog   218 GELPFAYI-TRVFDVF-------------------LVEGYKV--LFRVALALLKF-FHKVRGGQP 259

  Fly  1134 TASHAASHDLEMLGGEVLSMSTDEYRKTSLFATGSFD--------------------------LD 1172
            ..|:....|::|...::......|......||...|.                          :.
Frog   260 MESNNVKRDIQMFVRDLNQCVAPEKLLEKAFAIRLFSRKEIQLLQMANEKALQQKGITVKQKRVQ 324

  Fly  1173 FPIPDLIG--------KTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARL 1229
            .|:...:.        |:||::.:....:.|.:|.|.......|:::..:||   |||.|.....
Frog   325 SPVRQNVHLAVHAENFKSEIVSVKEMRDIWSWIPERFALSQPLLLYTNREHG---NSLSRFYLHC 386

  Fly  1230 E--SPVLIVIEDTEHNVFGALTSCSLHVSD-----------HFYGTGESLLYKFNPSFKVFHW-- 1279
            |  .|.|::|:.|...|.||..|     :|           .|:||||..:::..|..:.:.|
Frog   387 EGHEPTLLLIKTTNQEVCGAFLS-----TDWSERRRSGNKLSFFGTGECFVFRLQPEVERYEWVV 446

  Fly  1280 ------------TGEN----------------------------------MYFIKGNMESLSIGA 1298
                        :|:|                                  ..|:.|:.:.:.||.
Frog   447 IKHPELGKVNASSGDNDANSSQSAKDGIDPSDRLSPFLATRHFNLPSKSASMFMAGSTDCIIIGG 511

  Fly  1299 GDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAF 1343
            |||: .|:.|.|||.||:..|:|:.|:||. .|.|.|..:|.|.|
Frog   512 GDGQ-ALYFDSDLNYGRTSHCNTFNNQPLC-SETFQISIIEVWGF 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	56/223 (25%)
tbc1d24.1	XP_012826017.1	RabGAP-TBC	48..253	CDD:366170	50/252 (20%)
tbc1d24.1	XP_012826017.1	TLDc	342..554	CDD:214733	55/221 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910