DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtd and MEAK7

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_065998.3	Gene:	MEAK7 / 57707	HGNCID:	29325	Length:	456	Species:	Homo sapiens

Alignment Length:	425	Identity:	100/425 - (23%)
Similarity:	156/425 - (36%)	Gaps:	52/425 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 GRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPARACLDPP 1011
            |||....|:....:|.......|...|.:|.:..:|. |:           |.:.......|.|.
Human     9 GRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSF-SL-----------KALQNHVGEALPPE 61

  Fly  1012 LYLRLRMGKPIGKAIPLPTSVMSYGKNKLRAEYWFSVP---KNRVDELYRFINTWVKHLYGELDE 1073
            :..||..|.   :.:.|........:|..:.::..|:.   |...:|....|...:....|.:..
Human    62 MVTRLYDGM---RRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKA 123

  Fly  1074 EQIKARGFELI----------QEDTEWTKSGTTKAGMGGGSQ--DGEEISDLTRESWELIKAPFA 1126
            .:::....:|:          ||...||  |....|.....|  ..:.:||:..:..:.:..|..
Human   124 REVQKFTEDLVGSVVHVLSHRQELRGWT--GKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQW 186

  Fly  1127 KTYKIIKTASHAASHDLEMLGGEVLSMSTDEYRKTSLFATGSFDLDFPIPDL-----IGKTEILT 1186
            ..|    ....|...|.......|....:....|..|....|.||...:|:.     .|...||.
Human   187 LDY----DCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGRGFESILD 247

  Fly  1187 EEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSC 1251
            ......:.:.|| |.:.:.|.|:||:..||.:.:.|...:.. ..|.:.|:||.:.:|||...||
Human   248 VLSVMYINAQLP-REQRHRWCLLFSSELHGHSFSQLCGHITH-RGPCVAVLEDHDKHVFGGFASC 310

  Fly  1252 SLHVSDHFYGTGESLLYKFNPSFKVFHWTGEN---MYFIKGNM---ESLSIGAGDGRFGLWLDGD 1310
            |..|...|.|.....|:...||..|:..||.|   ||...|..   ..|.:|.....||||:|.|
Human   311 SWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDVD 375

  Fly  1311 LNQGRSQ---QCSTYGNEPLAPQEDFVIKTLECWA 1342
            ..:|.|:   .|:||.:..|:.||:|....:|.||
Human   376 FGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWA 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	55/170 (32%)
MEAK7	NP_065998.3	TLDc	244..412	CDD:214733	55/169 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910