Protein Alignment mtd and TBC1D24

DIOPT Version :10

• Sequence 1: NP_001246928.1
• Gene: mtd / 45467
• FlyBaseID: FBgn0013576
• Length: 1344
• Species: Drosophila melanogaster
• Sequence 2: NP_001186036.1
• Gene: TBC1D24 / 57465
• HGNCID: 29203
• Length: 559
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 109/533 - (20%)
• Similarity: 196/533 - (36%)
• Gaps: 160/533 - (30%)

  Fly   929 PVPPLTPH-STHSEGHMTYGRSSIGTFIRPHSS-----------------------EGTSSSTKL 969
            |...:||. |.:|:        .:|..:..|||                       ||......|
Human    63 PCRTVTPDASVYSD--------IVGKIVGKHSSSCLPLPEFVDNTQVPSYCLNARGEGAVRKILL 119

  Fly   970 KEAKQAPKLDY----RSMVSM-----DDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPI--G 1023
            ..|.|.|.:.:    .::|::     .|:.|.|....:::     ||.||        |:.:  .
Human   120 CLANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRIL-----ACNDP--------GRRLIDQ 171

  Fly  1024 KAIPLPTSVMSYGKNKLRAEYWFSVPKNRV---DELYRFINTWVKHLYGELD-------EEQIKA 1078
            ..:...:|.|::|  .|..:|..:..|..|   :::.:....|.:.|:|||.       .:....
Human   172 SFLAFESSCMTFG--DLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGELPLCYFARVFDVFLV 234

  Fly  1079 RGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDL---------TRESWELIKAPFA------KT 1128
            .|::::............|...|...:......|:         |....:|::..||      |.
Human   235 EGYKVLYRVALAILKFFHKVRAGQPLESDSVKQDIRTFVRDIAKTVSPEKLLEKAFAIRLFSRKE 299

  Fly  1129 YKIIKTASHAASHDLEMLGGEV----LSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEH 1189
            .::::.|:..|   |:..|..|    :|:|..::...::.|...            ::||::...
Human   300 IQLLQMANEKA---LKQKGITVKQKSVSLSKRQFVHLAVHAENF------------RSEIVSVRE 349

  Fly  1190 REKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLH 1254
            ...:.|.:|.|.......|:||:.|||::|...|.:....| |.|::|:.|:..|.||..|....
Human   350 MRDIWSWVPERFALCQPLLLFSSLQHGYSLARFYFQCEGHE-PTLLLIKTTQKEVCGAYLSTDWS 413

  Fly  1255 VSDH------FYGTGESLLYKFNPSFKVFHWT--------------------------------- 1280
            ..:.      |:||||..:::..|..:.:.|.
Human   414 ERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPPPLMAAEPTAPLSHSASSDPADR 478

  Fly  1281 ---------------GENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQ 1330
                           .|:| |:.|..:.|.:|.|.|: .|::|||||:||:..|.|:.|:||. .
Human   479 LSPFLAARHFNLPSKTESM-FMAGGSDCLIVGGGGGQ-ALYIDGDLNRGRTSHCDTFNNQPLC-S 540

  Fly  1331 EDFVIKTLECWAF 1343
            |:|:|..:|.|.|
Human   541 ENFLIAAVEAWGF 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	<250..371	CDD:440998
		TLDc	1182..1344	CDD:214733	56/216 (26%)
TBC1D24	NP_001186036.1	RabGAP-TBC	48..253	CDD:459855	37/212 (17%)
		TLDc	342..554	CDD:214733	56/216 (26%)