DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and oxr1a

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_021322409.1	Gene:	oxr1a / 571418	ZFINID:	ZDB-GENE-080219-14	Length:	804	Species:	Danio rerio

Alignment Length:	1107	Identity:	280/1107 - (25%)
Similarity:	436/1107 - (39%)	Gaps:	345/1107 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 VPDNFKNRSRRASQDVSSLSRSVDNLAIPVRRSKSRSVDHGLAAPFDLDSLRSKVEQRFESVDKL 314
            :|....|||...:...:: |...:|.....:|...|..|  |...:.:|:.:.|..::     |.
Zfish    29 IPSLSLNRSSPPAAKTNT-SEVQENNTTNAQRRVPRCSD--LKRGYTIDTGQKKTPEK-----KD 85

  Fly   315 SRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHLNRLNSSFIYPGQQLLVPDKSAKDDA 379
            .|:.|......||.|:|.:||||.::|.:|||||:||..||:|.|..:.|||.|.|||......|
Zfish    86 GRRMSFQRPKGTIEYSVESRDTLNNIALKFDTTPNELVQLNKLFSRNVVPGQVLYVPDPEYVSSA 150

  Fly   380 SSSSTHDADGASLSGKSSPVE-RKLSGDESREKDILEGLRPGSPKPGHIERVGGSSQQQQAEEEA 443
            .||.:. :..:.||..||..: .|::.|.:...      |..:|.|..:..:..|.......||
Zfish   151 GSSPSF-SPSSPLSPTSSEADLEKVTTDSNGPP------RSDAPAPPVLSALRSSRVVSSTSEE- 207

  Fly   444 NKSDDPVITQRFLKINVRHITDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGPESYGVIAPMEL 508
                :..:|::|||||.::||||:|||.||||||||.:||||:.:||||:|.|.|.||::.|:|.
Zfish   208 ----EEALTEKFLKINCKYITDGKGVVSGVLLVTPNNIMFDPHRTDPLVLEKGCEEYGIMCPLEE 268

  Fly   509 VVNAAIFHDIAHMRVAGGAGQGLNSASGDAEKPEIYYPKPVLVEEDSKELPEQQSLLGEDGNKRL 573
            |.:||::.:|...::                                           .|....|
Zfish   269 VQSAAVYKEIIDSKI-------------------------------------------RDSVTDL 290

  Fly   574 DAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVEDSSMEA------KDSAKTDALDDEDKKA 632
            :|...|.....||....:||.      |::.:....||...|:      ::...|:.|..|||.:
Zfish   291 EAVFSSFSHQTDQRYDSASTA------PRSTEGSFSEDVFTESELSPIREEHQSTEELQQEDKSS 349

  Fly   633 GLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSVSGVPL 697
            |....|.::.|:|               .:|..:|.||:.....|:...:||..::...
Zfish   350 GASSQSVKTLLQE---------------PQSHTEEKDNDGEPAGDTAKPIQDEPTSRDH------ 393

  Fly   698 SQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREPVPNVQPIPKKTVYS 762
            .|.|........|...:||      .|:      :|::....||..|:.|
Zfish   394 QQTPHCQTEGEPAAQESSA------EGV------KLTRDGTRDSETDVEE--------------- 431

  Fly   763 DADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGGAGGVRK--KTSSVSFSVDD-EAAQ 824
                                                        :||  ||.::..:.:. |:.|
Zfish   432 --------------------------------------------LRKMCKTHTMQQAKEQRESVQ 452

  Fly   825 QAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNT 889
            |||.:|      ::|..:::   :|||
Zfish   453 QAQRES------EQQTTEQS---QRLS-------------------------------------- 470

  Fly   890 GDSNQSVFSKVFSSSPITLVSELGGNLFSKTPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSIGTF 954

Zfish   471 ----------------------------------------------------------------- 470

  Fly   955 IRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPARACLDPPLYLRLRMG 1019
                |:||...|   ||.:::.|                                   :|.||:|
Zfish   471 ----SAEGPVVS---KERQKSHK-----------------------------------FLCLRVG 493

  Fly  1020 KPIGKAI--PLPTSVMSYGKNKLRAEYWFSVPKNRVDELYRFINTWVKHLYGELDEEQIKARGFE 1082
            |.:.|..  ....|:..|.:...:.||||:||:.|.|.||.|...|...::|:         |..
Zfish   494 KAMKKTFVSNASASMQQYAQRDRKHEYWFAVPQERSDHLYVFFIQWSPDVFGD---------GLG 549

  Fly  1083 LIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRESWELIKAPFAKTYKIIKTASHAASHDLEMLG 1147
            .|..|..:......:.......|..||.|:   :.||::.  :.:.::.|...:   |.||..|.
Zfish   550 SISRDPGFIVVKKIEESEANEEQQPEENSE---KEWEVVS--WTEYHRRIDALN---SEDLRSLC 606

  Fly  1148 GEV-LSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFS 1211
            ..: ::...|...|.....|.|.:.:...|:|...:::|..|..|||..|||.|..||.|:|.||
Zfish   607 KRLQITTKEDVNSKHGTSITASLEPETFKPNLNEPSDLLEAEQIEKLAKHLPPRTIGYPWNLAFS 671

  Fly  1212 TSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKV 1276
            ||:||.::.:|||.|...:||:|:||:|::..:||||.|....||:.||||||:.|:.|.|.|:.
Zfish   672 TSKHGMSIKTLYRAMQDQDSPMLLVIKDSDGQIFGALASEPFKVSEGFYGTGETFLFTFYPEFEA 736

  Fly  1277 FHWTGENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECW 1341
            :.|||:|::||||:|:||:.|.|.|.|||||||||..||:..|.|:||..|:.:|||.::.:|.|
Zfish   737 YKWTGDNLFFIKGDMDSLAFGGGSGEFGLWLDGDLYHGRNHSCKTFGNPMLSMKEDFFVQDIEIW 801

  Fly  1342 AF 1343
            :|
Zfish   802 SF 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306	34/99 (34%)
		LysM	329..371	CDD:279777	22/41 (54%)
		TLDc	1182..1344	CDD:214733	82/162 (51%)
oxr1a	XP_021322409.1	LysM	100..142	CDD:307567	22/41 (54%)
		PHA00666	361..>465	CDD:222808	30/201 (15%)
		Pex26	<444..>490	CDD:311234	18/199 (9%)
		TLDc	642..804	CDD:214733	82/162 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384247at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010