DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtd and evi5l

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_009291813.3	Gene:	evi5l / 566318	ZFINID:	ZDB-GENE-061207-24	Length:	996	Species:	Danio rerio

Alignment Length:	457	Identity:	92/457 - (20%)
Similarity:	144/457 - (31%)	Gaps:	161/457 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   902 SSSPITLVSELGGNLFSKTPSEDSG------------GSPVPPLTPHSTHSEGHMTYGRSSIGTF 954
            ||||     |..|.:......||..            ||||  |:|.|:..:..::...:|
Zfish     5 SSSP-----EREGGMAGSVQLEDLNSPAGLEIDPPFIGSPV--LSPDSSSHDAALSAPAAS---- 58

  Fly   955 IRPHSSEGTSSS-----TKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPARACLDPPLYL 1014
              |..||..|..     .||:|..:..:.|.:||.||...
Zfish    59 --PADSENLSPDELELLAKLEEQNRLLEADSKSMRSMSGS------------------------- 96

  Fly  1015 RLRMGKPIGKAIPLPTSVMSYGKNKLRAEYWFSVPK--NRVDELYRFINTWVKHLYGELDEEQIK 1077
            |...|..:     :.:|..|...::|..:.|....:  |..||..|..:..:|.|..:......:
Zfish    97 RRNSGSSL-----VSSSSASSNLSQLEEDTWILWGRIVNEWDEWRRKKDKLLKELIRKGIPHHFR 156

  Fly  1078 ARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRES---WELIKAPFAKTYKIIKTASHAA 1139
            |..::|:...|:....              .:.|:|.:.|   .:||:...|:||         .
Zfish   157 AIVWQLLCNATDMPVK--------------NQYSELLKMSSPCEKLIRRDIARTY---------P 198

  Fly  1140 SHDL----EMLGGEVL-------SMSTDE--YRKTSLFATGSFDLDFPIPDLIGKTEILTEEHRE 1191
            .||.    :.||.|||       |:...|  |.:.|.|..|...:..|            ||  |
Zfish   199 EHDFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMP------------EE--E 249

  Fly  1192 KLCSHLPARAEGYSWSLIFSTSQHGFALNSLYR-KMARLESPVLIVIEDTEHNVFGALTSCSLHV 1255
            ..|              :|......:.|..|:: .||.|.    :.|...||.:...|...::|.
Zfish   250 AFC--------------VFVRLMQEYRLRELFKPSMAELG----LCIYQFEHLLQEQLPELNVHF 296

  Fly  1256 SDHFYGTGE-------SLLYKFNP------SFKVFHWTGENMYF--------------IKGNMES 1293
            ....:.|..       :|...|.|      .|.:|.:.|..:.|              |:.:||.
Zfish   297 RSQSFHTSMYASSWFLTLFLTFLPLPIATRIFDIFMYEGLEIIFRVGIAILQYNQTDLIQLDMEG 361

  Fly  1294 LS 1295
            :|
Zfish   362 MS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	27/142 (19%)
evi5l	XP_009291813.3	TBC	147..355	CDD:214540	48/262 (18%)
		SMC_N	<395..>757	CDD:330553
		C2H2 Zn finger	865..886	CDD:275368
		C2H2 Zn finger	915..935	CDD:275368
		COG5048	923..>991	CDD:227381
		C2H2 Zn finger	943..963	CDD:275368
		C2H2 Zn finger	971..991	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910