Protein Alignment mtd and OXR1

DIOPT Version :10

• Sequence 1: NP_001246928.1
• Gene: mtd / 45467
• FlyBaseID: FBgn0013576
• Length: 1344
• Species: Drosophila melanogaster
• Sequence 2: NP_001185461.1
• Gene: OXR1 / 55074
• HGNCID: 15822
• Length: 874
• Species: Homo sapiens
• Alignment Length: 1082
• Identity: 309/1082 - (28%)
• Similarity: 455/1082 - (42%)
• Gaps: 308/1082 - (28%)

  Fly   299 SLRSKVEQRFESVD---------KLSRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHL 354
            |.||:: :||.::|         |..|:.|......||.|||.:||:|.|:|.:|||||:||..|
Human    63 SRRSEL-KRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQL 126

  Fly   355 NRLNSSFIYPGQQLLVPDKSAKDDASSSSTHDADGASLSGKS--SPVERKLSGDESREKDI---- 413
            |:|.|..:..||.|.|||........||       .|||..|  ||...:...|::...|:
Human   127 NKLFSRAVVTGQVLYVPDPEYVSSVESS-------PSLSPVSPLSPTSSEAEFDKTTNPDVHPTE 184

  Fly   414 ------LEGLRPGSPKPGHIERVGGSSQQQQAEEEANKSDDPVITQRFLKINVRHITDGQGVVGG 472
                  ..|:||.        ||..|:.:   ||||       .|::|||||.::||.|:|.|.|
Human   185 ATPSSTFTGIRPA--------RVVSSTSE---EEEA-------FTEKFLKINCKYITSGKGTVSG 231

  Fly   473 VLLVTPNAVMFDPNVSDPLVIEHGPESYGVIAPMELVVNAAIFHDIAHMRVAGGAGQGLNSASGD 537
            |||||||.:||||:.:||||.|:|.|.||::.|||.|::||::.:|
Human   232 VLLVTPNNIMFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEI------------------- 277

  Fly   538 AEKPEIYYPKPVLVEEDSKELPEQQSLLGEDGNKRLDAEI-GSLEIADDQESLCSSTGRDGDAFP 601
                                               ||::| .||.|..||.|     |||
Human   278 -----------------------------------LDSKIKESLPIDIDQLS-----GRD----- 297

  Fly   602 KAFDRERVEDSSMEAKDSAKTDALDDEDKKAGLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSED 666
             ....:::..|:.|..||...||.:|....|      .|||.|    ||        |:|..:|.
Human   298 -FCHSKKMTGSNTEEIDSRIRDAGNDSASTA------PRSTEE----SL--------SEDVFTES 343

  Fly   667 EGDNESNVTVDSGARVQDPHSANSSVSGVPLSQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLE 731
            |........|.|....||..|..||.|...::|    |...:..|...|...|        .||.
Human   344 ELSPIREELVSSDELRQDKSSGASSESVQTVNQ----AEVESLTVKSESTGTP--------GHLR 396

  Fly   732 QLSKQSCYDSGIDIREPVPNVQPIPKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQS 796
            ..::.|..:.|           .:..||..::.::.:..|.      :..:|.
Human   397 SDTEHSTNEVG-----------TLCHKTDLNNLEMAIKEDQ------IADNFQ------------ 432

  Fly   797 LDAGTGGAGGVRKKTSSVSFSVDDEA--------AQQAQAQSAALAVTDKQADKKNKMLKRLSYP 853
                  |..|.::.::|:..:.|.::        .:::|.::.....|   |:.|.|.
Human   433 ------GISGPKEDSTSIKGNSDQDSFLHENSLHQEESQKENMPCGET---AEFKQKQ------- 481

  Fly   854 LTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNTGDSNQSVFSKVFSSSPITLVSELGGNLFS 918
                             .|..|...|..:.||     .:......|::.:..:....:...|:..
Human   482 -----------------SVNKGKQGKEQNQDS-----QTEAEELRKLWKTHTMQQTKQQRENIQQ 524

  Fly   919 KTPSEDSGGSPVPPLTPHS-THSEGHMTYGRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRS 982
            .:..|          ..|. |.::||:                   .||..||| ||..:|.
Human   525 VSQKE----------AKHKITSADGHI-------------------ESSALLKE-KQRHRLH--- 556

  Fly   983 MVSMDDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPIGKAIPLPTS--VMSYGKNKLRAEYW 1045
                                         .:|.||:|||:.|......|  :..|.:...:.|||
Human   557 -----------------------------KFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYW 592

  Fly  1046 FSVPKNRVDELYRFINTWVKHLYGELDEEQIKARGFELIQ--EDTEWTKSGTTKAGMGGGSQDGE 1108
            |:||:.|.|.||.|...|...:|.|...|..:..||.:::  |::|..:..:.:|.
Human   593 FAVPQERTDHLYAFFIQWSPEIYAEDTGEYTREPGFIVVKKIEESETIEDSSNQAA--------- 648

  Fly  1109 EISDLTRESWELIKAPFAKTYKIIKTASHAASHDLEMLGGEVLSMSTDEYRKTSLFATGSFDLDF 1173
                 .|| ||::..  |:.::.|...:   :.:|..|... |.::|.|...:...||...||:.
Human   649 -----ARE-WEVVSV--AEYHRRIDALN---TEELRTLCRR-LQITTREDINSKQVATVKADLES 701

  Fly  1174 PI--PDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIV 1236
            ..  |:|...:|:|..:..|||..|||.|..||.|:|::.|.:||.:|.:|||.|..|::|||:|
Human   702 ESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMV 766

  Fly  1237 IEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDG 1301
            |:|::..|||||.|..|.|||.||||||:.::.|.|.|:||.|||:||:||||:|:||:.|.|.|
Human   767 IKDSDGQVFGALASEPLKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGG 831

  Fly  1302 RFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAF 1343
            .|.|||||||..|||..|.|:||..|:.:|||.|:.:|.|||
Human   832 EFALWLDGDLYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAF 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	<250..371	CDD:440998	33/80 (41%)
		TLDc	1182..1344	CDD:214733	88/162 (54%)
OXR1	NP_001185461.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..89		7/26 (27%)
		LysM	<23..145	CDD:440998	35/82 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..194		10/49 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..406		34/136 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..537		20/165 (12%)
		Mediates oxidative antimutator activity	551..578		10/58 (17%)
		TLDc	712..874	CDD:214733	88/162 (54%)