DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtd and Tbc1d10a

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_001015022.1	Gene:	Tbc1d10a / 360968	RGDID:	1311641	Length:	505	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	110/588 - (18%)
Similarity:	170/588 - (28%)	Gaps:	219/588 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 AKDDASSSSTHDADGASLSGKSSPVERKLSGDESREKDILEGLRPGSPKPGHIER--------VG 431
            ||....:.....|.|.||||..   |....|.::...|.|..|...|...|..||        ||
  Rat     2 AKSSRENGPRAPASGGSLSGTR---ESLAQGPDAATADELSSLGSDSEANGFAERRIDKFGFIVG 63

  Fly   432 GSSQQQQAEE---------EANKSD-----DPVITQRFLKINVRHITDG----------QGVVGG 472
            ....:...||         |:...|     |..:.::..||.:| ...|          |.:.||
  Rat    64 SQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLR-CQKGIPPSLRGRAWQYLSGG 127

  Fly   473 VLLVTPNAVMFDP---NVSDPLVIEHGPESYGVIAPMELVVNAAI-----FHDIAHMRVAGGAGQ 529
            .:.:..|...||.   :..||..::              |:...:     ||::...|  ||.||
  Rat   128 KVKLQQNPGKFDELDMSPGDPKWLD--------------VIERDLHRQFPFHEMFVSR--GGHGQ 176

  Fly   530 G-----LNSASGDAEKPEIYY---PKPV----------------LVEEDSKELPEQQSLLGEDGN 570
            .     |.:.:  ..:||..|   ..|:                ||:...|.||...|
  Rat   177 QDLFRVLKAYT--LYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQVCEKYLPGYYS------- 232

  Fly   571 KRLDAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVEDSSMEAK----DSAKT--------- 622
            ::|:|      |..|.|.|.|...:......|...|::::......:    ..|:|
  Rat   233 EKLEA------IQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRV 291

  Fly   623 -DALDDEDKKA--GLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQD 684
             |....|..|.  .:||            .||.|....|.|.|:.:.:.:....:...|...:|:
  Rat   292 WDMFFCEGVKIIFRVGL------------VLLKHALGSPEKLRACQGQYETIEQLRSLSPKIMQE 344

  Fly   685 PHSANSSVSGVPLSQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREP- 748
            .......:.                        :|:....|:.|||.||.:.......::.|.|
  Rat   345 AFLVQEVIE------------------------LPVTERQIEREHLIQLRRWQETRGELECRSPP 385

  Fly   749 -------VPNVQPIPKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGGAGG 806
                   :.:.:|.|:..:.....|.|     ||...:|:  |::.|.
  Rat   386 RMHGAKAILDAEPGPRPALQPSPSIRL-----PPDAALPS--SKTKPH----------------- 426

  Fly   807 VRKKTSSVSFSVDDEAAQQAQAQSAALAVTDKQADKKNKMLKRLSYP-----LTWVEGLTGEGGA 866
                                           |||.|:.|..|....|     |.....:|..|.|
  Rat   427 -------------------------------KQAQKEQKRTKTSGQPDKSPGLNQATVVTASGDA 460

  Fly   867 VPP 869
            .||
  Rat   461 CPP 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733
Tbc1d10a	NP_001015022.1	TBC	110..313	CDD:214540	46/245 (19%)
Tbc1d10a	NP_001015022.1	VCX_VCY	404..>501	CDD:291884	20/115 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910