DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and TBC1D9

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_055945.2	Gene:	TBC1D9 / 23158	HGNCID:	21710	Length:	1266	Species:	Homo sapiens

Alignment Length:	1155	Identity:	200/1155 - (17%)
Similarity:	337/1155 - (29%)	Gaps:	433/1155 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KSDKSQKRRSSIAVS------------------------FLRRDSSKNSTKDSYESAVRSEKSDG 105
            |:|.|....|.:::|                        ||::.:||          :.|:|...
Human   359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSK----------IYSDKEFA 413

  Fly   106 SGTPTSPEIVYSSEENIRASSP------NDPGKQTFFEDGSQSPRPVLQGLNTSYEGPQNDRQRR 164
            ....:|.:.|||...::.:|||      :..|::.|..:|:..| ...|.|.|.|       :||
Human   414 GSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVP-TATQTLMTMY-------RRR 470

  Fly   165 RRSSLQTKLDRHRRKKMEYSNQRSLDSGMMC---SESHSDLTNDSLAEG---------SGSFANR 217
            .......||.:...|:..:....:.....:|   :|...:|....:.|.         ||:...:
Human   471 SPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEK 535

  Fly   218 SRNGNDDEDDIIDPSHGEY------FPREKRHSWWNIFVPDN--FKNRSRRASQDVSSLSRSVDN 274
            :.:....| |:::.|.|:|      ..|:...|     :|::  |:|     ...:::|.|.:..
Human   536 ATHPGYYE-DLVEKSMGKYNLATEEIERDLHRS-----LPEHPAFQN-----EMGIAALRRVLTA 589

  Fly   275 LAIPVRRSKSRSVDHGLAAPFDLDS----LRSKVEQRF---------------------ESVDKL 314
            .|.       |:.:.|.....::.:    |.:|.|:.|                     ..||:.
Human   590 YAF-------RNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQG 647

  Fly   315 SRQKSSLPTIPTISYTVGNRDTLTSVAARFDTT------PSELTHLNRLNSSFIYPGQQLLVP-- 371
            ..::.:...:|.:...:.:...:::::..:..|      |.|...:  :...|.|.|.:::..
Human   648 VFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVV--VVDCFFYEGIKVIFQLA 710

  Fly   372 --------DK--SAKDDASSSSTHDADGASLSGKSS-----PVERKLSGDESR---EKDILEGLR 418
                    ||  :.|||..:.:.......|::.|.|     |....|..|:..   |.||...:|
Human   711 LAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIR 775

  Fly   419 PGSPKPGHIERVGGSSQQQQAEEEANKSDDPVITQRFLKINVRHITDGQGVVGGVLLVTPNAVMF 483
            ....|.|.|              .|:..:.....||...|.....|..:.||.  .:||..:...
Human   776 TSYEKFGTI--------------RADLIEQMRFKQRLKVIQTLEDTTKRNVVR--TIVTETSFTI 824

  Fly   484 DPNVSDPLVIEHGPESYGVIAPMELVVNAAIFHDIAHMRVA--GGAGQGLNSASGDAEKPEIYYP 546
            |                      ||....|:| ...|:...  ||:...|     |...|.:.|.
Human   825 D----------------------ELEELYALF-KAEHLTSCYWGGSSNAL-----DRHDPSLPYL 861

  Fly   547 KPVLVE-EDSKEL-----------------PEQQSLLGEDGNKRLDAEIGSLEIADDQESLCSST 593
            :...:: |..|.:                 .....||.|:|    |:.|...|......:.|
Human   862 EQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDENG----DSLINFREFVSGLSAAC--- 919

  Fly   594 GRDGD------------AFPKAFDRERVEDSSMEAKDSAKTDALDDEDKKAGLGLSSTRSTLEER 646
              .||            ..|:....:...||:.||......|...:
Human   920 --HGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDITPE------------------- 963

  Fly   647 RKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSVSGVPLSQPPVAAAAAAAAV 711
                ..|...:.|:.:...|:|....::..|.|.|.....:.|......|
Human   964 ----CTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTP--------------- 1009

  Fly   712 APASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREPVPNVQPIPK----------KTVYSDADI 766
                               |..||..             |.:.:||          ||:|:
Human  1010 -------------------ENKSKSK-------------NAKDLPKLNQGQFIELCKTMYN---- 1038

  Fly   767 VLSSDWVPPKTIVPTHFSESPPRSTI-------------LGQ---------SLDAGTGGAG---- 805
                           .|||.|....:             :|:         :.:.|:||:|
Human  1039 ---------------MFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGSGGSGPSCH 1088

  Fly   806 ----GV--RKKTSSVSFSVDDEAAQQAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEG 864
                ||  .||.....:.|     :..:...|:||...::.....:|           |.:..|.
Human  1089 QGIPGVLFPKKGPGQPYVV-----ESVEPLPASLAPDSEEHSLGGQM-----------EDIKLED 1137

  Fly   865 GAVPPGGVGSGSLNKSGDTDSAPNTGDSNQSVFSKVFSSSPITLVSELGGNLFSKTPSEDSGGSP 929
            .:....|..|..|....||..     ||:.|.:|          |...|.:...|...||.|...
Human  1138 SSPRDNGACSSMLISDDDTKD-----DSSMSSYS----------VLSAGSHEEDKLHCEDIGEDT 1187

  Fly   930 VPPLTPHSTHSEGHMTYGRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFI 994
            |               ..||..||...|.|:                .||....::.    |.|:
Human  1188 V---------------LVRSGQGTAALPRST----------------SLDRDWAITF----EQFL 1217

  Fly   995 SVDKLIPRPARA-CLDPPLYLRLR---------MGKPIGKAIPLPTSVMS 1034
            :  .|:..||.. ..|.|:.:..|         ||||:..|.....|.||
Human  1218 A--SLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYEISAMS 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306	16/130 (12%)
		LysM	329..371	CDD:279777	6/47 (13%)
		TLDc	1182..1344	CDD:214733
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..456		10/40 (25%)
		TBC	512..722	CDD:214540	33/229 (14%)
		EFh	<893..923	CDD:385324	9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1095		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1164		8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910