Protein Alignment mtd and Tbc1d24

DIOPT Version :9

• Sequence 1: NP_001246928.1
• Gene: mtd / 45467
• FlyBaseID: FBgn0013576
• Length: 1344
• Species: Drosophila melanogaster
• Sequence 2: NP_001157319.1
• Gene: Tbc1d24 / 224617
• MGIID: 2443456
• Length: 561
• Species: Mus musculus
• Alignment Length: 555
• Identity: 117/555 - (21%)
• Similarity: 212/555 - (38%)
• Gaps: 160/555 - (28%)

  Fly   896 VFSKVFSSSPITLV-------SELGGNLFSKTPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSIGT 953
            |:.::....|...|       |::.|.:..|   ..|...|:|....:            :.:.|
Mouse    54 VYQRLIRDIPCRTVTPDASVYSDIVGKIVGK---HSSSSLPLPEFVDN------------TQVPT 103

  Fly   954 FIRPHSSEGTSSSTKLKEAKQAPKLDY----RSMVSM-----DDKPELFISVDKLIPRPARACLD 1009
            :......||......|..|.|.|.:.:    .::|::     .|:.|.|....:::     :|.|
Mouse   104 YCLNTRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRIL-----SCND 163

  Fly  1010 PPLYLRLRMGKPIGKA-IPLPTSVMSYGKNKLRAEYWFSVPKNRV---DELYRFINTWVKHLYGE 1070
            |       ..|.|.:: :...:|.|::|  .|..:|..:..|..|   :::.:..:.|.:.|:||
Mouse   164 P-------TKKLIDQSFLAFESSCMTFG--DLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGE 219

  Fly  1071 LDEEQIKARGFELIQEDTEWTK------------SGTTKAGMGGGSQDGEE-----ISDL--TRE 1116
            |..... ||.|::..  .|..|            ....:||....|.:.::     :.|:  |..
Mouse   220 LPLNYF-ARVFDVFL--VEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVS 281

  Fly  1117 SWELIKAPFA------KTYKIIKTASHAASHDLEMLGGEV----LSMSTDEYRKTSLFATGSFDL 1171
            ..:|::..||      |..::::.|:..|   |...|..|    :|:|..::...::.|...
Mouse   282 PEKLLEKAFAIRLFSRKEIQLLQMANEKA---LRQKGITVKQKSVSLSKRQFVHLAVHAENF--- 340

  Fly  1172 DFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIV 1236
                     .:||::.:....:.|.:|.|.......|:||:.|||::|:..|.:....| |.|::
Mouse   341 ---------HSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHE-PTLLL 395

  Fly  1237 IEDTEHNVFGALTSCSLHVSDH--------FYGTGESLLYKFNPSFKVFHWT------------- 1280
            |:.|:..|.||..|...  |:.        |:||||..:::..|..:.:.|.
Mouse   396 IKTTQKEVCGAYLSTDW--SERTKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKATSL 458

  Fly  1281 -------------------------------------GENMYFIKGNMESLSIGAGDGRFGLWLD 1308
                                                 .|:|:...|| :.|.||.|.|: .|::|
Mouse   459 KSSEAAGSSSLISHCSSDPADRLSPFLAARHFNLPSKTESMFMAGGN-DCLIIGGGGGQ-ALYVD 521

  Fly  1309 GDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAF 1343
            ||||:||:..|.|:.|:||. .|:|:|..:|.|.|
Mouse   522 GDLNRGRTGHCDTFNNQPLC-SENFLIAAVEAWGF 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	58/220 (26%)
Tbc1d24	NP_001157319.1	RabGAP-TBC	48..253	CDD:278964	42/230 (18%)
		DUF499	<265..>358	CDD:303008	17/107 (16%)
		Phosphatidylinositol binding. /evidence=ECO:0000250|UniProtKB:Q9VIH7	293..297		0/3 (0%)
		TLDc	342..556	CDD:214733	58/220 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810