DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and tbc-7

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_001359912.1	Gene:	tbc-7 / 180784	WormBaseID:	WBGene00016292	Length:	679	Species:	Caenorhabditis elegans

Alignment Length:	698	Identity:	146/698 - (20%)
Similarity:	261/698 - (37%)	Gaps:	174/698 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 DSGIDIREPVP-NVQPIPKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGG 803
            |:..|..|.|| .|.....:|..|:.|....:::...:...|.:     |:: ::..:||    |
Worm    50 DTSGDEDETVPARVGQAAGRTDDSEVDNDEGNNFFRFQRAAPVY-----PKN-MINHNLD----G 104

  Fly   804 AG--GVRKKTSS---VSFSVDDEAAQQAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGE 863
            |.  |:|:.|||   :|.::........:|::       :.|.::.::|         ||
Worm   105 AATTGMRRTTSSIARISMAIRRSLRLPRRAET-------RMAAREEQVL---------VE----- 148

  Fly   864 GGAVPPGGVGSGSLNKSGDT----DSAPNTGD--------SNQSVFSKVFSSSPITLVSELGGNL 916
              .:|.|.:.:   ..:.||    .|.||...        :......|:...:...:..|:..||
Worm   149 --PIPEGPLFT---ENTRDTRIGESSVPNLLQEIVDNKRLNRYEKVKKIIRRTDWPVCHEIRANL 208

  Fly   917 FSK-TPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSIGTFIRPH---SSEGTSSSTKLKEA----- 972
            :.: ..::|..||       ...:|:..:.|.|.:.|....|.   ...|..|:..|||.
Worm   209 WKELCNTKDWSGS-------KRLYSDEAIEYDRINQGKKQSPQILADEGGVLSNFDLKEVGSVKL 266

  Fly   973 --------KQAPKLDYRSMV----SM-----DDKPELFISVDKLIPRPARACLDPPLYLRLRMGK 1020
                    :..|::.|...:    |:     ||..:.|..::.|        |:...||   |..
Worm   267 IRLLLIIERLRPEIVYAPSIYPLCSLLLHFNDDDGDCFACINYL--------LNTKGYL---MTA 320

  Fly  1021 PIGKAIPLPTSVMSYGKNKLRAEYWFSVPKNRV---DE--LYRFINTWVKHLYGELDEEQI---- 1076
            |:..|....|.:....|:|..|   :.:.|.|:   |:  |.:.|..|:..|:..|....|
Worm   321 PVQWAASSHTILALVKKHKSAA---YVLLKRRLGTTDDSVLVKCIEDWLLWLFQYLPLPYICRIV 382

  Fly  1077 ---KARGFE-LIQEDTE----WTKSGTTKAGMGG--GSQDGEEISDLTRESWELIKAPFAKTYKI 1131
               .|.|.: ||:....    |:|  ..|.||..  |....|:|..:.:|..::.......|...
Worm   383 DCYFAEGHKFLIRSAISIVYIWSK--VHKRGMEDFRGKSLQEKIDSIKKEFQDVATNISVSTSTF 445

  Fly  1132 IKTA---SHAASHDLEMLGGEVLSMSTDE----------YRKTSLFATGSFDLDFPIPDLIGKTE 1183
            |.||   .:..|..:..|..:......||          .|:| :|....            |:.
Worm   446 IATAVKIRNLQSATIAKLQAQFEDELRDEVTSRPRQIKKVRRT-IFCEAF------------KSC 497

  Fly  1184 ILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGAL 1248
            ::..:...:|.|::|.|.:..:.:|.:..||.|.:..:.:.|:..|:. .:|:|:.|...:|||.
Worm   498 LVDNDSAVELMSYMPPRLQLVTPTLAYQLSQDGTSFYNFWSKVDPLDQ-TIIIIKSTCGAIFGAY 561

  Fly  1249 TSCSLHVSDH----------FYGTGESLLYKFNPSF---KVFHWTGEN---------MYFIKGNM 1291
              ||...|:.          ::|||||.:::.|...   :::.|.|.:         .||:....
Worm   562 --CSSTWSERHDRKERTRSKYWGTGESYVFRMNKEMELPEIYTWVGNSPDVSSDKCPQYFMSATD 624

  Fly  1292 ESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLE 1339
            :|..||:| ||..:.:|.:|..|.:...||:.:..|.....|.|..||
Worm   625 KSFVIGSG-GRDAIRIDEELTHGITGPSSTFNSPQLCEDGAFDIYELE 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	45/180 (25%)
tbc-7	NP_001359912.1	TBC	196..409	CDD:214540	48/235 (20%)
tbc-7	NP_001359912.1	TLDc	498..672	CDD:214733	45/178 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910