DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and lmd-3

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_505173.2	Gene:	lmd-3 / 179225	WormBaseID:	WBGene00018700	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	1086	Identity:	300/1086 - (27%)
Similarity:	459/1086 - (42%)	Gaps:	301/1086 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 FESVDKLSRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHLNRLNSSFIYPGQQLLVPD 372
            |.||..:....:.:|.. .:.||:...|||..|||..|.|..||..||::.|..::|||::|||.
Worm     4 FGSVSSVPPGSAKIPAF-QMDYTITETDTLERVAASHDCTVGELMKLNKMASRMVFPGQKILVPL 67

  Fly   373 KSAKDDASSSSTHDADGASLSGKSSPVERKLSGDESREKDILEGLRPGSPKPGHIERVGGSSQQQ 437
            .:|.|      ..|...::.|.|||  ..::||.|:.|..|.:|  ||...|.|:.|  ||..:.
Worm    68 ANADD------VFDPPSSASSLKSS--GNQISGIENAEDGIRKG--PGGAVPAHVRR--GSFTKT 120

  Fly   438 QAEEEANKSDDPVIT---QRFLKINVRHITDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGPES 499
            |:......|:|...|   ||||||.|:.:|:..|.|.|.||||||.:||||:||.|||.|:||:.
Worm   121 QSAPIPRGSNDEADTDCLQRFLKIKVKQVTESDGTVSGTLLVTPNCLMFDPDVSHPLVKENGPDL 185

  Fly   500 YGVIAPMELVVNAAIFHDIAHMRVAGGAGQGLNSASGD-AEKP-EIYYPKPVLVEEDSKELPEQQ 562
            ||::|.|:.:.:.:::.:|:          ||   :|| |||. :|:.|..:...|||.:...:|
Worm   186 YGMVANMDEIQSVSVYKEIS----------GL---TGDKAEKKRDIFDPDHLRTPEDSPKKQIKQ 237

  Fly   563 SLLGEDGNKRLDAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVEDSSMEAKDSAKTDALDD 627
            :              |.:|||.::|....:...|.:..||......:...|.|.|||...:|..|
Worm   238 N--------------GEIEIAKNEEVAFEAGSVDSNHSPKFGSDIALPAISEETKDSPCEEAKGD 288

  Fly   628 EDKKAGLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSV 692
                    ||..||.      :|.|....:.::.|:|.....|:           :.|.|.:.
Worm   289 --------LSRNRSA------TLGDEEIQLRARSRTSSQASSND-----------ERPRSFSE-- 326

  Fly   693 SGVPLSQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLE-QLSKQSCYDSGIDIREPVPNVQPIP 756
                                     :..|..|.::.... ..:::|....|..:.....::|
Worm   327 -------------------------LDTPSEGKNIGRFSPNAARRSFGKLGRTLSARAKSIQ--- 363

  Fly   757 KKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGGAGGVRKKTSSVSFSVDDE 821
             .||.|.|:.|:.:.....||:                         |.||...|.|.:.::...
Worm   364 -GTVTSGAEKVVGTAVQGTKTV-------------------------AHGVVTHTKSAADTLQSG 402

  Fly   822 AAQQAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSA 886
            ....|:   ||..|..:..||...::                          |.|:|...:..|.
Worm   403 IENGAK---AAADVAGRVVDKGQSLM--------------------------SESINGVTEIFSV 438

  Fly   887 PNTGDSNQSVFSKVFSSSPITLVSELGGNLFSKTPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSI 951
            |   |..|.      :.||:.:..|.     |....:|
Worm   439 P---DFEQP------AKSPLAMKREQ-----SLAKLQD--------------------------- 462

  Fly   952 GTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPR------PARACLDP 1010
               :|..::|...:|.|...|..     :....|.|:.|:||.:||:::.|      .:.|...|
Worm   463 ---LRRQTAEARENSAKENHAGV-----FACATSSDEAPDLFAAVDEIMERNRIQSNDSTASQSP 519

  Fly  1011 --PLYLRLRMGKPIGKAIPLPTSVMSYGK-----NKLRAEYWFSVPKNRVDELYRFINTWVKHLY 1068
              |.|:.:|:.:. .|.....||..||.:     |||:.|:||:||:|:.|.:|.|:..|....|
Worm   520 ILPFYMAVRLTRN-KKKKKSSTSSPSYDEDIAFGNKLKREFWFAVPRNQADNIYHFLLQWSPDKY 583

  Fly  1069 GELDEEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRESWELIKAPFAKTYKIIK 1133
            | ||                  |.:.||:......|.||::                 |.:.::
Worm   584 G-LD------------------TTTSTTEEPSSVMSNDGQD-----------------KGFIVL- 611

  Fly  1134 TASHAASHDLEMLGGEVLSMSTDEYRKTSLFATG------------------SFD--LDFPIPDL 1178
                 .|:..|.||||         :.|.||.:.                  |.|  |:.||||.
Worm   612 -----GSNADESLGGE---------KSTPLFGSSLLNREWELVTVSEMCRRLSLDQELELPIPDG 662

  Fly  1179 IGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLE---SPVLIVIEDT 1240
            ...::||.|....::...||.|||||.|..|:::.:|||:|.::|||||..:   ||||::|.||
Worm   663 AATSQILDELMIRQVMDILPPRAEGYPWVNIYNSEKHGFSLATMYRKMAEFDEDLSPVLLIIRDT 727

  Fly  1241 EHNVFGALTSCSLHVSDHFYGTGES-LLYKF------NPSFKVFHWTGENMYFIKGNMESLSIGA 1298
            :.:||||:.|.::..:|||:|||:| ||::|      ....:.::|||:|.||:....:||||||
Worm   728 KEHVFGAVVSSAIRPNDHFFGTGDSCLLWRFTGEVPHTRELRQYNWTGDNQYFVNAAKDSLSIGA 792

  Fly  1299 GDGRFGLWLDGDLNQGRSQQCSTYGNEPL-APQEDFVIKTLECWAF 1343
            |.||.|||||.|||.|.||:|.|:.|||| ...:||:|:.:|.:.|
Worm   793 GSGRNGLWLDADLNHGSSQKCETFDNEPLCGDDQDFIIQFIEAYGF 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306	23/62 (37%)
		LysM	329..371	CDD:279777	19/41 (46%)
		TLDc	1182..1344	CDD:214733	80/173 (46%)
lmd-3	NP_505173.2	LysM	24..66	CDD:366664	19/41 (46%)
lmd-3	NP_505173.2	TLDc	666..838	CDD:214733	79/171 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159504
Domainoid	1	1.000	175	1.000	Domainoid score	I2187
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128779
Inparanoid	1	1.050	349	1.000	Inparanoid score	I1349
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28619
OrthoDB	1	1.010	-	-		D384247at33208
OrthoFinder	1	1.000	-	-		FOG0001020
OrthoInspector	1	1.000	-	-		oto18148
orthoMCL	1	0.900	-	-		OOG6_100646
Panther	1	1.100	-	-	LDO	PTHR23354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R882
SonicParanoid	1	1.000	-	-		X2069
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940