DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and Oxr1

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_036015097.1	Gene:	Oxr1 / 170719	MGIID:	2179326	Length:	879	Species:	Mus musculus

Alignment Length:	1081	Identity:	314/1081 - (29%)
Similarity:	453/1081 - (41%)	Gaps:	326/1081 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 QRFESVD---------KLSRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHLNRLNSSF 361
            :||.::|         |..|:.|......||.|||.:||:|.|:|.:|||||:||..||:|.|..
Mouse    81 KRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQLNKLFSRA 145

  Fly   362 IYPGQQLLVPDKSAKDDASSSSTHDADGASLSGKS--SPVERKLSGDESREKDI----------- 413
            :..||.|.|||........||       .|||..|  ||...:...|::...|:
Mouse   146 VVTGQVLYVPDPEYVSSVESS-------PSLSPVSPLSPTSSEAEFDKTTTPDVAHPKEAPPAST 203

  Fly   414 LEGLRPGSPKPGHIERVGGSSQQQQAEEEANKSDDPVITQRFLKINVRHITDGQGVVGGVLLVTP 478
            :.|:||.        ||..|:.:   ||||       .|::|||||.::||.|:|.|.|||||||
Mouse   204 VSGIRPA--------RVVSSTSE---EEEA-------FTEKFLKINCKYITIGKGTVSGVLLVTP 250

  Fly   479 NAVMFDPNVSDPLVIEHGPESYGVIAPMELVVNAAIFHDIAHMRVAGGAGQGLNSASGDAEKPEI 543
            |.:||||:.:||||.|:|.|.||::.|||.|::||::.:|
Mouse   251 NNIMFDPHKTDPLVQENGCEEYGIMCPMEEVMSAAMYKEI------------------------- 290

  Fly   544 YYPKPVLVEEDSKELPEQQSLLGEDGNKRLDAEI-GSLEIADDQES---LCSSTGRDG----DAF 600
                                         ||::| .||.|..||.|   .|.|....|    ||.
Mouse   291 -----------------------------LDSKIKESLPIELDQLSGRGSCHSKKATGVSAEDAD 326

  Fly   601 PKAFDRERVEDSSMEAKDSAKTDALDDEDKKAGLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSE 665
            |:|  |::..||:..|..|.:....:|         :.|.|.|...|:.||...   |.:::||
Mouse   327 PRA--RDQGNDSASTAPRSTEESLSED---------AFTESELSPIREELLSSE---PRQEKSS- 376

  Fly   666 DEGDNESNVTVDSGARVQDPHSANSSVSGVP--LSQPPVAAAAAAAAVAPASAVVPLPPSGIDLE 728
             :..:||..|| |...||. .:|.|..:.||  .|..|.|                       |.
Mouse   377 -DASSESVQTV-SQMEVQS-LTATSEAANVPDRTSSNPGA-----------------------LS 415

  Fly   729 HLEQLSKQSCYDSGIDIREPVPNVQPI--PKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRST 791
            |...||.......|.|  :...::|.:  ||:                              :||
Mouse   416 HETGLSGLETATKGGD--KATESLQEVSGPKE------------------------------QST 448

  Fly   792 -ILGQSLDAGTGGAGGVRKKTSSVSFSVDDEAAQQAQAQSAALAVTDKQA---DKKNKMLKRLSY 852
             :.||.           .:.:|....|:..||.:.:.:....:.:.:|.|   |::.:.|||.|.
Mouse   449 EVKGQD-----------NQDSSHQESSLQQEAGEDSVSSGETVELKEKPAVLKDQQGQELKRDSE 502

  Fly   853 PLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNTGDSNQSVFSKVFSSSPITLVSELGGNLF 917
              |.||.|.              .|.|:.....|....|:.|.|
Mouse   503 --TEVEELR--------------KLWKTHSMQQAKQQRDTIQQV--------------------- 530

  Fly   918 SKTPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRS 982
            |:..|:.|..:.       ..|.||                       |:.||| |:..:|.
Mouse   531 SQRESKHSSAAA-------DAHGEG-----------------------SSLLKE-KRRHRLH--- 561

  Fly   983 MVSMDDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPIGKAIPLPTS--VMSYGKNKLRAEYW 1045
                                         .:|.||:|||:.|......|  :..|.:...:.|||
Mouse   562 -----------------------------KFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYW 597

  Fly  1046 FSVPKNRVDELYRFINTWVKHLYGELDEEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEI 1110
            |:||:.|.|.||.|...|...:|.|...|..:..||.::::..| :::....||
Mouse   598 FAVPQERTDHLYAFFIQWSPEIYAEDSGEYTREPGFIVVKKMDE-SEANEAPAG----------- 650

  Fly  1111 SDLTRESWELIKAPFAKTYKIIKTASHAASHDLEMLGGEVLSMSTDEYRKTSLFATGSFDLDFP- 1174
             :.....||::..  |:.::.|...:   :.:|..|... |.::|.|...:...|....||: |
Mouse   651 -EAAAREWEVVSV--AEYHRRIDALN---TEELRTLCRR-LQITTREDINSKQVAPAKADLE-PE 707

  Fly  1175 --IPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVI 1237
              .|:|...:|:|..:..|||..|||.|..||.|:|::.|.:||.:|.:|||.|..|::|||:||
Mouse   708 SFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVI 772

  Fly  1238 EDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDGR 1302
            :|::..|||||.|....|||.||||||:.::.|.|.|:||.|||:||:||||:|:||:.|.|.|.
Mouse   773 KDSDGQVFGALASEPFKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGE 837

  Fly  1303 FGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAF 1343
            |.|||||||..|||..|.|:||..|:.:|||.|:.:|.|||
Mouse   838 FALWLDGDLYHGRSHSCKTFGNHTLSKKEDFFIQDIEIWAF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306	30/73 (41%)
		LysM	329..371	CDD:279777	22/41 (54%)
		TLDc	1182..1344	CDD:214733	87/162 (54%)
Oxr1	XP_036015097.1	LysM	113..155	CDD:396179	22/41 (54%)
		MDN1	<278..562	CDD:227596	97/521 (19%)
		TLDc	717..879	CDD:214733	87/162 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3312
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1913
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384247at33208
OrthoFinder	1	1.000	-	-		FOG0001020
OrthoInspector	1	1.000	-	-		otm43759
orthoMCL	1	0.900	-	-		OOG6_100646
Panther	1	1.100	-	-	LDO	PTHR23354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R882
SonicParanoid	1	1.000	-	-		X2069
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860