DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtd and TLDC2

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	NP_542195.1	Gene:	TLDC2 / 140711	HGNCID:	16112	Length:	215	Species:	Homo sapiens

Alignment Length:	170	Identity:	82/170 - (48%)
Similarity:	114/170 - (67%)	Gaps:	0/170 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly  1172 DFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIV 1236
            |..:|.|...:::|:.....:|..|.|.|..|:.|||:|.||:.||:|.||||:|.....|||:|
Human    43 DPTVPQLTEASQVLSASEIRQLSFHFPPRVTGHPWSLVFCTSRDGFSLQSLYRRMEGCSGPVLLV 107

  Fly  1237 IEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDG 1301
            :.|.:..:|||.:|.::.:|..||||||:.|:.|:|..|||.|||.|.:|:||:::||.:|:|.|
Human   108 LRDQDGQIFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGSNSFFVKGDLDSLMMGSGSG 172

  Fly  1302 RFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECW 1341
            ||||||||||.:|.|..|.|:.||.||.||.|.|:.||.|
Human   173 RFGLWLDGDLFRGGSSPCPTFNNEVLARQEQFCIQELEAW 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	79/160 (49%)
TLDC2	NP_542195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		1/2 (50%)
TLDC2	NP_542195.1	TLDc	53..212	CDD:214733	78/158 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384247at33208
OrthoFinder	1	1.000	-	-		FOG0001020
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100646
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R882
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.680