DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and Sgsm3

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_006520307.1	Gene:	Sgsm3 / 105835	MGIID:	1916329	Length:	761	Species:	Mus musculus

Alignment Length:	884	Identity:	176/884 - (19%)
Similarity:	275/884 - (31%)	Gaps:	295/884 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 HMRVAGGAGQGLNSASG--DAEKPEIYYPKPVLVEEDSK-ELPEQQSLLGEDGNKRLDAEIGSLE 581
            ||.    :|....||||  .|..|.| :|:.:|.:...| |..||..|..::...|:|.|.||
Mouse     9 HMM----SGNHTPSASGPFSALTPSI-WPQEILAKYSQKEESSEQPELCYDEFGFRVDKEEGS-- 66

  Fly   582 IADDQESLCSS-TGRDGDAFPKAFDRERVEDSSMEAKDSAKTDALDDEDKKAG------LGLSST 639
                 |..||. ||           ...|||.....:..|..:...:.|  .|      :.:|..
Mouse    67 -----EPGCSQMTG-----------SPLVEDPPQRLRWQAHLEFTHNHD--VGDLTWDKIAVSLP 113

  Fly   640 RS-------------------------TLEERRKSLLDHHWAIPSKDRSSEDEGDNESNV----- 674
            ||                         .|::::.|.|.:...|.:   ||.||......:
Mouse   114 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKKNSELSYREIIKN---SSNDETIAAKQIEKDLL 175

  Fly   675 -TVDSGARVQDPHSANSSVSGVPLSQ----------PPVAAAAAAAAVAPASAVVPLPPSGIDLE 728
             |:.|.|..     ||.:..|||..:          |.:........||....:.        ||
Mouse   176 RTMPSNACF-----ANVNSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLF--------LE 227

  Fly   729 H----------LEQLSKQSCYDS---GIDIREPVPN---VQPIPK-KTVYSDADIVLS---SDWV 773
            .          :|.|...|.:.:   |:...:.|..   ||.:|: ..:..:.||.||   ..|.
Mouse   228 EEDAFWMMCAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWF 292

  Fly   774 PPKTIVPTH-----------FSESPPRSTILGQSLDAGTGGAGGVRKKTSSVSFSVDDEAAQQAQ 827
            ........|           |.|.   |.:|.|:.      .|.:|.|        ::|..|...
Mouse   293 LTAFASVVHIRLLLRIWDLFFYEG---SLVLFQTT------LGMLRLK--------EEELIQSEN 340

  Fly   828 AQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNTGDS 892
            :.|....::|..|...:            .|.|.||...:      :|||     ||.|..|...
Mouse   341 SASIFNTLSDIPAQMDD------------AELLLGEAMRL------AGSL-----TDVAVETQRR 382

  Fly   893 NQSVFSKVFSSSPITLVSELGGNLFSKTPSEDSGGSPVPPLTPHSTHSEGHMTYGRSSIGTFIRP 957
            ....:          |:::.|..|.:.|.:..|  ..|...|.........:.:|...:
Mouse   383 KHLAY----------LIADQGQTLGTGTTTNLS--QVVRRRTQRRKSGITSLLFGEDDL------ 429

  Fly   958 HSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPAR--ACLDPPLYLRLRMGK 1020
                   .:.|.|..||.               ||...:.:.|.|.||  .|.||         |
Mouse   430 -------EALKAKNIKQT---------------ELVADLREAILRVARHFQCTDP---------K 463

  Fly  1021 PIGKAIPLPTSVMSYGK-----------NKLRAEYWFSVPKNRVDEL-YR------FINTWVKHL 1067
            .....:....|:.|:.:           ::.||:......::..||| :|      .|:...:|.
Mouse   464 NCSVELTPDYSMESHQRDHENYVACLRSHRRRAKALLDFERHDDDELGFRKNDIITIISQKDEHC 528

  Fly  1068 Y-GELD--EEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRES-WELIKAPF--- 1125
            : |||:  .....|:..|::.|.::       :..:.|.....|.::||.|.: ...:||.|
Mouse   529 WVGELNGLRGWFPAKFVEVLDERSK-------EYSIAGDDSVTEGVTDLVRGTLCPALKALFEHG 586

  Fly  1126 AKTYKIIKTASHAASHDLEMLGGEVLSMSTDEYRKTSLFATGSFD-------------------- 1170
            .|...::..|.|......|..|.||.......|.:..|..|...|
Mouse   587 LKKPSLLGGACHPWLFIEEAAGREVERDFDSVYSRLVLCKTYRLDEDGKVLTPEELLYRAVQSVN 651

  Fly  1171 ---------LDFPIPDLI--GKTEILTEEHREKLCSHLPARAEGYS-WSLIFSTSQ--------- 1214
                     :|..:..||  |..|.:.....|.|||.||...:.|. ||.:.|...
Mouse   652 VTHDAAHAQMDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRV 716

  Fly  1215 ---HGFALNSLYRKMARLE---SPVLIVIED--TEHNVF 1245
               ..|:|:..:...||.|   .|:...::|  .:|::|
Mouse   717 LCCFAFSLSQDWELPARREEEKQPLKEGVQDMLVKHHLF 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306
		LysM	329..371	CDD:279777
		TLDc	1182..1344	CDD:214733	20/82 (24%)
Sgsm3	XP_006520307.1	TBC	125..336	CDD:214540	44/243 (18%)
		SH3_SGSM3	495..547	CDD:212747	12/51 (24%)
		RUN	574..725	CDD:367169	30/150 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910