DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtd and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001246928.1	Gene:	mtd / 45467	FlyBaseID:	FBgn0013576	Length:	1344	Species:	Drosophila melanogaster
Sequence 2:	XP_002666912.2	Gene:	tbc1d2b / 100330777	ZFINID:	ZDB-GENE-100922-148	Length:	946	Species:	Danio rerio

Alignment Length:	517	Identity:	105/517 - (20%)
Similarity:	183/517 - (35%)	Gaps:	144/517 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 AAPFD-----LDSLRSKVEQRFESVDKLSRQKSSLPTI-PTISYTVGNRDTLTSVAARFDTTPSE 350
            |.|::     ::|:|:......::...:..|.:.:|.. ||.:        |:|:........:.
Zfish   163 AMPYEKPSESMESVRNDFALELDNDGLIGHQTAHVPVAQPTAA--------LSSLRQWGSEIRNS 219

  Fly   351 LTHL-------NRLNSSFIYPG--QQLLVPDKSAKDDASSSSTHDADGASLSGKSSPVERKLSGD 406
            ::||       ||  .|..|.|  :...:.|...||.|.|...| .:.:|...:|| :....:.|
Zfish   220 MSHLRPGRAGENR--RSVFYTGGSEDWEMVDPPTKDPAPSDCQH-RESSSHFNRSS-IGSAFTFD 280

  Fly   407 ESREKDILEGLRPGSPKPGH------IE-----------RVGGSSQQQ---QAEEEANKSDDPVI 451
            ......|......||.||.|      :|           |:  .|||:   |.:|:.||..:.:.
Zfish   281 FRNPSKIKRPFHSGSGKPNHSAESSPVEYNETKISKLQLRI--QSQQEEISQLQEQENKLREELG 343

  Fly   452 TQ----RFLKINVRHI-TDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGPESYGVIAPME---- 507
            :|    |.|:..:|.. .|....||      |:....:.|..|..:.|...:...:.:.||
Zfish   344 SQKELVRLLQKTLRSAQCDWPSTVG------PHNHYLEENEVDKALTERDTQIKDLCSHMEKLAL 402

  Fly   508 ------------------------LVVNAAIFHDIAHMRVAGGAGQG------LNSASGDAEKPE 542
                                    :::......|...|:::..:|:|      .||.|...|:.|
Zfish   403 EKESLQQELKGLKIKVGEINEQLGMLMETIQAKDEVIMKLSQPSGEGETQSAECNSPSVTREQQE 467

  Fly   543 IYYPKPVLVEEDS------KELPEQQSLL--GEDGNKRLDAEIGSLE-------------IADDQ 586
            :...|..|....|      ||:.|...|.  .|...|.|:|:..|||             :.:.:
Zfish   468 LNTLKDSLQGYKSQNKFLNKEIIELTVLRRNAESREKLLEAKYNSLEAKLCQVESKYLVLLQEVK 532

  Fly   587 ESLCSSTGR--DGDAFPKAF-DRERVEDSSMEAKDSAKTDAL--------------DDEDKKAGL 634
            ..:|||:.:  .||...:.. |..:||.:..:.....|.:|:              :||::|
Zfish   533 SPVCSSSEQTHSGDVITRLLEDALQVESTDQQEHPVLKPNAVSEYDIYGFKTVPEEEDEEEK--- 594

  Fly   635 GLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSVSGVP 696
             |.:.:..|:.:..||.|...::..|       .||...:|::. ..|:.|........|||
Zfish   595 -LEAKKRALDLKSLSLTDQETSVRVK-------WDNYLAITMNR-EMVRSPDLKALMRGGVP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtd	NP_001246928.1	LysM	271..371	CDD:224306	17/93 (18%)
		LysM	329..371	CDD:279777	9/50 (18%)
		TLDc	1182..1344	CDD:214733
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457	22/115 (19%)
		TPR_MLP1_2	313..434	CDD:285204	21/128 (16%)
		USP8_interact	317..>359	CDD:286082	12/43 (28%)
		TBC	643..859	CDD:214540	3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910