DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex1 and PEX1

DIOPT Version :9

Sequence 1:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	1135	Identity:	296/1135 - (26%)
Similarity:	483/1135 - (42%)	Gaps:	294/1135 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IRSNFVLLPDQYYGVVSTYDTGCLSLQYNGRTHYASWAPQKGGGGIKDTEIGINARAA------- 70
            |..||:.||.....|:.:             |:||          |::..|.:::..:
Yeast    20 IVGNFLRLPHSIINVLES-------------TNYA----------IQEFGIAVHSHNSDIPIVHL 61

  Fly    71 ----KEIGLHENDLVKCALIADV--LNLRS------------------VHVTPVSSKDWEIIELS 111
                .:.|..||.::...::|.|  ||.:|                  |:|||.:|.|||||:.:
Yeast    62 GWDGHDSGSSENVVLINPVLATVYDLNQKSPLVDLYIQRYDHTHLATEVYVTPETSDDWEIIDAN 126

  Fly   112 TEKI-SGSVLEQTRIVNSTQILIVWINKSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYK--- 172
            ..:. :|.:|.|||||...:.||.:: :.:.....:||::|.|...||...:.:||||.:.|
Yeast   127 AMRFQNGEILHQTRIVTPGETLICYL-EGIVTKFKIDRVEPSMKSARITDGSLVVVAPKVNKTRL 190

  Fly   173 -----GLTNGT--SNGVIEENTKLSRSKTTAQV---KDEL-----TEKLTPLTHSSTVSNVKNTI 222
                 |.:|.|  .||.|:...|:....|..::   ||.|     ::.....:.....|.||.::
Yeast   191 VKAEYGHSNKTILKNGAIQLLKKVILRSTVCKMDFPKDNLFVVYISDGAQLPSQKGYASIVKCSL 255

  Fly   223 QRNKRQDHMER------------LKKDLRRESSRSFEFRVIRGLWREQAQESDVF----VNGKHL 271
            :::|:.|...:            :|.|.:...:   ...:...||       |.|    :||..:
Yeast   256 RQSKKSDSDNKSVGIPSKKIGVFIKCDSQIPEN---HIALSSHLW-------DAFFTHPMNGAKI 310

  Fly   272 P-EFFDLDLFYCMHTAADKDYYVRVRTVEDDIEDDLPETIHPSIELNANLMKLLGIKELERVVLR 335
            . ||..::.   .:..:.::..|.::....|:         |: :......||||...|...::.
Yeast   311 KLEFLQMNQ---ANIISGRNATVNIKYFGKDV---------PT-KSGDQYSKLLGGSLLTNNLIL 362

  Fly   336 PKTTVVNFVEK---------IELFANKKTHYKI--MENAFKRFVIERTQHKPMLFNQEEVVRL-- 387
            |...::..::|         :...:|:...:|:  |.....:.:|||  |.|..::.:|...:
Yeast   363 PTEQIIIEIKKGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIER--HLPKHYHVKETGEVSR 425

  Fly   388 ----EDDLLVTVGILPEHFRYCVVDAQFLKESKIYAADLVRPVGEIIKEETPPTSPLSVQDLIQL 448
                |||.:....|..|...|.                               |||     :|..
Yeast   426 TSKDEDDFITVNSIKKEMVNYL-------------------------------TSP-----IIAT 454

  Fly   449 PEYDKIVDQVVQELRMNLCLSADNSVMRQCNVLLAGASGTGKTVLVERILDQLSRK----PDYCH 509
            |.                             ::|.|..|.|||.|::.:::::.:.    ..|..
Yeast   455 PA-----------------------------IILDGKQGIGKTRLLKELINEVEKDHHIFVKYAD 490

  Fly   510 FEFFHGSRSKGRKTESIQKDLRNIF---TSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYNR- 570
            .|..|       :|.::.|..:.|.   :.|..:.|:::||:|::.|   .|:..:.||:..|.
Yeast   491 CETLH-------ETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEAL---FGKPQANDGDPSNNG 545

  Fly   571 ---MADTVYQLIVQYTT------NNAIAVIATVNELQTLNKRLSSPRGRHVFQTVARLPNLERAD 626
               .|..:....:...|      |..|.|:.:..:...:|..|..   :|.......|...::..
Yeast   546 QWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFD---KHFVSETWSLRAPDKHA 607

  Fly   627 REIILRELCSHINVAK---DLDLVKFSNLTEGYRKCDLVQFVERAIFYAYRISK-TQPLLTNDQL 687
            |..:|....|...:.|   ||.....|..|||:...||..|.|: |||..::.: ...::|.:..
Yeast   608 RAKLLEYFFSKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEK-IFYDLQLERDCDNVVTRELF 671

  Fly   688 IESLEHTNSYCLQGIQSNQRTGNDADANEMRVEELPGLESVVGVLEEVLMWPSRYPTIFNASPLR 752
            .:||.......|:|::..:.|       .::..::..|.:...||.|.|.||::|..||...|||
Yeast   672 SKSLSAFTPSALRGVKLTKET-------NIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLR 729

  Fly   753 NQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVL 817
            .::|:||||.||.|||.|.|.:|....|..|||||||:|.|:||.||:|:|.||.||:|.:||:|
Yeast   730 LRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCIL 794

  Fly   818 FFDEFDSLAPKRGHDSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRL 882
            |||||||:|||||||||||||||||||||::||.|||.||.::||||||:|:|.||||.||:|:.
Yeast   795 FFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKS 859

  Fly   883 VECPLPDAPARVRIFEALSST---------LSLDECVDFDWFAGKTANYTGADIQSILTSANMAA 938
            |.|.:|....|:.|.:|:.::         .:|::..|....|.|||.::|||:|.:..:|.:.:
Yeast   860 VICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKS 924

  Fly   939 VKEALA--------------------QFG---HEKLAKKISLKQ--------------------- 959
            |...|:                    :.|   ..:|..|..|:|
Yeast   925 VHRWLSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASELTAVVT 989

  Fly   960 -KHLIESFQTTRPSLSASDVAKYHRTYARF 988
             ..|:|:.|.|:||:|.|::.|....|.||
Yeast   990 INDLLEACQETKPSISTSELVKLRGIYDRF 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361	28/93 (30%)
		SpoVK	479..974	CDD:223540	185/569 (33%)
		P-loop_NTPase	480..604	CDD:304359	29/140 (21%)
		AAA	757..887	CDD:278434	88/129 (68%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267	27/75 (36%)
		SpoVK	457..929	CDD:223540	173/492 (35%)
		RecA-like_PEX1_r2	705..862	CDD:410934	100/156 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346432
Domainoid	1	1.000	183	1.000	Domainoid score	I689
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I441
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto100023
orthoMCL	1	0.900	-	-		OOG6_103335
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R902
SonicParanoid	1	1.000	-	-		X3465
TreeFam	1	0.960	-	-
	13	12.780