Protein Alignment Pex1 and CDC48

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 878
• Identity: 223/878 - (25%)
• Similarity: 375/878 - (42%)
• Gaps: 177/878 - (20%)

  Fly   204 EKLTPLTHSSTV-----SNVKNTIQRNKRQDHM----ERLKKD---LRRESSRSFEFRVIRGLWR 256
            |:..||..:|.|     ......|.|.|::|:|    :.:..|   :...|:...:..:.||
Yeast     3 EEHKPLLDASGVDPREEDKTATAILRRKKKDNMLLVDDAINDDNSVIAINSNTMDKLELFRG--- 64

  Fly   257 EQAQESDVFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDDIEDDLPETIHPSIELNANLM 321
                 ..|.|.||                 ..|| .|.:..::|::||.       :..:|..:.
Yeast    65 -----DTVLVKGK-----------------KRKD-TVLIVLIDDELEDG-------ACRINRVVR 99

  Fly   322 KLLGIKELERVVLRPKTTVVNFVEKIELFANKKTHYKIMENAFKRFVIERTQHKPMLFNQEEVVR 386
            ..|.|:..:.|.:.| ...:.:..:|.:.....|...|..|.|..|:      ||........||
Yeast   100 NNLRIRLGDLVTIHP-CPDIKYATRISVLPIADTIEGITGNLFDVFL------KPYFVEAYRPVR 157

  Fly   387 LEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAAD-LVRPVGEIIKEETPPTS------------ 438
            ..|..:|..|:....|:  |||.: .:|..:.|.| ::...||.|..|....:
Yeast   158 KGDHFVVRGGMRQVEFK--VVDVE-PEEYAVVAQDTIIHWEGEPINREDEENNMNEVGYDDIGGC 219

  Fly   439 ---PLSVQDLIQLPEYDKIVDQVVQELRMNLCLSADNSVMRQCNVLLAGASGTGKTVLVERILDQ 500
               ...::::::||            ||......| ..:.....||:.|..|||||::...:.::
Yeast   220 RKQMAQIREMVELP------------LRHPQLFKA-IGIKPPRGVLMYGPPGTGKTLMARAVANE 271

  Fly   501 LSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDG 565
            ..     ..|...:|.....:.....:.:||..|....::||||:.::.:|.:   |.::...:|
Yeast   272 TG-----AFFFLINGPEVMSKMAGESESNLRKAFEEAEKNAPAIIFIDEIDSI---APKRDKTNG 328

  Fly   566 EYYNRMADTVYQLIVQYTTNNAIAVIATVNELQTLNKRLSSPRGRHVFQTVARLPNLERADREI- 629
            |...|:...:..|:......:.:.|||..|...:::..|.               ...|.|||:
Yeast   329 EVERRVVSQLLTLMDGMKARSNVVVIAATNRPNSIDPALR---------------RFGRFDREVD 378

  Fly   630 -----------ILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVERAIFYAYRISKTQPLLT 683
                       :||....::.:|.|:||...:..|.||...|:......|..  .:|.:...|:.
Yeast   379 IGIPDATGRLEVLRIHTKNMKLADDVDLEALAAETHGYVGADIASLCSEAAM--QQIREKMDLID 441

  Fly   684 ND------QLIESLEHTNSYCLQGIQSNQRTGNDADANEMRVE-------ELPGLESVVGVLEEV 735
            .|      ::::||..|    :...:......|.:...|..||       ::.||:.:...|:|.
Yeast   442 LDEDEIDAEVLDSLGVT----MDNFRFALGNSNPSALRETVVESVNVTWDDVGGLDEIKEELKET 502

  Fly   736 LMWPSRYP---TIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKGPELLAKYIGQ 797
            :.:|..:|   |.|..||.:   |||.|||||||||.|...:||..:...|||||||||:.:.|:
Yeast   503 VEYPVLHPDQYTKFGLSPSK---GVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGE 564

  Fly   798 SEENVRNLFNRARSARPCVLFFDEFDSLAPKRG---HDSTGVTDRVVNQLLTELDGVEGLQGVTV 859
            ||.|:|::|::||:|.|.|:|.||.||:|..||   .|:.|.:||||||||||:||:...:.|.|
Yeast   565 SESNIRDIFDKARAAAPTVVFLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKKNVFV 629

  Fly   860 IAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDECVDFDWFAGKTANYTG 924
            |.||:||:.:|||:||.||:|:|:..||||..||:.|..|......|:..::....|..|..::|
Yeast   630 IGATNRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRKTPLEPGLELTAIAKATQGFSG 694

  Fly   925 ADIQSILTSANMAAVKEALAQFGHEKLAKKISLK--------------------------QKHLI 963
            ||:..|:..|...|:|:::......:..|::.::                          ::|..
Yeast   695 ADLLYIVQRAAKYAIKDSIEAHRQHEAEKEVKVEGEDVEMTDEGAKAEQEPEVDPVPYITKEHFA 759

  Fly   964 ESFQTTRPSLSASDVAKYHRTYARFTNKEKTSR 996
            |:.:|.:.|:|.:::    |.|..::.:.|.||
Yeast   760 EAMKTAKRSVSDAEL----RRYEAYSQQMKASR 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729
		CDC48	365..983	CDD:273521	184/690 (27%)
		RecA-like_PEX1_r2	728..885	CDD:410934	81/162 (50%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	209/828 (25%)