Protein Alignment Pex1 and AFG2

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_013501.1
• Gene: AFG2 / 851113
• SGDID: S000004389
• Length: 780
• Species: Saccharomyces cerevisiae
• Alignment Length: 918
• Identity: 230/918 - (25%)
• Similarity: 389/918 - (42%)
• Gaps: 199/918 - (21%)

  Fly   116 SGSVLEQTRIVNSTQILIVWINKSMQVALTVDRL-KPHMNYGRIDHNTELVVA---PNLYKGLTN 176
            |||..:.:...||...      |:.:..|..:.: :||.:.   ||..|...|   ||:...|..
Yeast     8 SGSKKKSSASSNSADA------KASKFKLPAEFITRPHPSK---DHGKETCTAYIHPNVLSSLEI 63

  Fly   177 GTSN----GVIEENTKLSRSKTTAQVKDELTEKLTPLTHSSTVSNVKNTIQRNKRQDHMERLKKD 237
            ...:    |.|.||..|    ..|:..||....:..:|.|:|:.:|.|.|    ..|.:|..|..
Yeast    64 NPGSFCTVGKIGENGIL----VIARAGDEEVHPVNVITLSTTIRSVGNLI----LGDRLELKKAQ 120

  Fly   238 LRRESS--------------RSFEFRVIRGLWREQAQESDVFVNGKHLPEFFDLDLFYCMHT-AA 287
            ::...:              ...|.:||:.|    ..:|.|.:.|.         :|..:.| |.
Yeast   121 VQPPYATKVTVGSLQGYNILECMEEKVIQKL----LDDSGVIMPGM---------IFQNLKTKAG 172

  Fly   288 DKDYYVRVRTVEDDIEDDLPETIHPSIELNANLMKLLGIKELERV-------VLRPKTTVVNFVE 345
            |:...|   .:.|..:|.||:.    .:|:.|:..:.|  .|:.:       :.|..:|.:.|.:
Yeast   173 DESIDV---VITDASDDSLPDV----SQLDLNMDDMYG--GLDNLFYLSPPFIFRKGSTHITFSK 228

  Fly   346 KIELFANKKTHYKIMENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQ 410
            :.:  ||:|                        :|                 |||...|..
Yeast   229 ETQ--ANRK------------------------YN-----------------LPEPLSYAA---- 246

  Fly   411 FLKESKIYAADLVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMNLCLSADNSVM 475
                           ||.:.||..      |::..|::|.:..             .|.:...|.
Yeast   247 ---------------VGGLDKEIE------SLKSAIEIPLHQP-------------TLFSSFGVS 277

  Fly   476 RQCNVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQH 540
            ....:||.|..|||||:|: |::...|.    .|....:|.....:.....:..||:||....::
Yeast   278 PPRGILLHGPPGTGKTMLL-RVVANTSN----AHVLTINGPSIVSKYLGETEAALRDIFNEARKY 337

  Fly   541 APAIVVLENLDVLA-HAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNELQTLNKRL 604
            .|:|:.::.:|.:| :.|.:.|   ||..:|:..|:..|:........:.|||..|...:::..|
Yeast   338 QPSIIFIDEIDSIAPNRANDDS---GEVESRVVATLLTLMDGMGAAGKVVVIAATNRPNSVDPAL 399

  Fly   605 SSPRGRHVFQTVARLPNLE-RADREIILRELCSHINVAK---DLDLVKF-SNLTEGYRKCDLVQF 664
            ..| ||...:....:|::: |.|   ||.:..|.::..:   |.:.:|: ::.|.||...||...
Yeast   400 RRP-GRFDQEVEIGIPDVDARFD---ILTKQFSRMSSDRHVLDSEAIKYIASKTHGYVGADLTAL 460

  Fly   665 VERAIFYAYRISKT-QPLLTNDQLIE--SLEHTNSYCLQGIQSNQRTGNDADANEMRVE------ 720
            ...::.      || |..|..|..|:  ||:.|    |:.::|.......:...|:.:|
Yeast   461 CRESVM------KTIQRGLGTDANIDKFSLKVT----LKDVESAMVDIRPSAMREIFLEMPKVYW 515

  Fly   721 -ELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIIS 784
             ::.|.|.:...::|::..|......|....:....|||||||||..||.....|||...:..::
Yeast   516 SDIGGQEELKTKMKEMIQLPLEASETFARLGISAPKGVLLYGPPGCSKTLTAKALATESGINFLA 580

  Fly   785 VKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDSTGVTDRVVNQLLTELD 849
            |||||:..||:|:||..:|.:|.:||||.|.::||||.|:|:|.|...||...:.|:..||.|:|
Yeast   581 VKGPEIFNKYVGESERAIREIFRKARSAAPSIIFFDEIDALSPDRDGSSTSAANHVLTSLLNEID 645

  Fly   850 GVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDEC-VDFD 913
            |||.|:||.::|||:||:.:|.||||.||:||.:....||..||:.|.:..:...:.:|. ||..
Yeast   646 GVEELKGVVIVAATNRPDEIDAALLRPGRLDRHIYVGPPDVNARLEILKKCTKKFNTEESGVDLH 710

  Fly   914 WFAGKTANYTGADIQSILTSANMAAVKEALAQFGHEKLAKKISLKQKHLIESFQTTRPSLSASDV 978
            ..|.:|..|:||::..:...|.:||:.|.|      .:||   ::.:|..::|:.....:: .::
Yeast   711 ELADRTEGYSGAEVVLLCQEAGLAAIMEDL------DVAK---VELRHFEKAFKGIARGIT-PEM 765

  Fly   979 AKYHRTYA 986
            ..|:..:|
Yeast   766 LSYYEEFA 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	13/55 (24%)
		CDC48	365..983	CDD:273521	170/634 (27%)
		RecA-like_PEX1_r2	728..885	CDD:410934	69/156 (44%)
AFG2	NP_013501.1	CDC48	51..773	CDD:273521	217/864 (25%)