DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex1 and PEX1

DIOPT Version :9

Sequence 1:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_196464.2	Gene:	PEX1 / 830746	AraportID:	AT5G08470	Length:	1130	Species:	Arabidopsis thaliana

Alignment Length:	1142	Identity:	321/1142 - (28%)
Similarity:	506/1142 - (44%)	Gaps:	192/1142 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FVLLPDQYYGVVSTYDTGCLS--LQYNGRTHYASWAPQKGGGGIKDTEIGINARAAKEIGLHEND 79
            ||.||.|....:.:..:..|.  |....|:....|:....|.....:.|.|....|:.|.|.:..
plant    29 FVSLPRQLLHALQSTSSSPLPPLLPVELRSGDRRWSVAWSGSSSSSSAIEIARVFAESISLPDGT 93

  Fly    80 LVKCALIADVLNLRSVHVTPVSSKDWEIIELSTEKISGSVLEQTRIVNSTQILIVWINKSMQVAL 144
            :||..::.:|.....|.|.|.:..|||::||:.|....::|.|.||::.|....:|::....:..
plant    94 VVKVRVLPNVPKATLVTVEPETEDDWEVLELNAELAEAAILSQVRILHETMKFPLWLHDRTVIRF 158

  Fly   145 TVDRLKPHMNYGRIDHNTELVVAPNLY-KGLTNGTSNGVIEENTK-LSRSKTT-------AQVKD 200
            :|....|.....::...||:.|||... :.|....|......|.| |.|.:.|       |.||.
plant   159 SVVSTFPSKGVVQLVPGTEVAVAPKRRDRNLKAKKSQEKECNNVKALLRVQETDRSAFHEADVKG 223

  Fly   201 -ELTEKLTPLT--HSSTVS----------------------------NVKNTIQRNKRQDHMERL 234
             ||...||.:.  |..|..                            |:||:......::.....
plant   224 FELRVALTSIAYIHPETAKKHSLESLQLISVSPRIPLKGSAKKDEALNMKNSEASKVAENGTSSA 288

  Fly   235 KKDLRRESSR-SFEFRVIRG---------LWREQAQESDVFVNG------KHLPEFFDLDLFYCM 283
            ||:.|:...| .|.....:|         |:......|.|::.|      |.:|.   |.|..|:
plant   289 KKEPRQAILRLVFSDLAAKGHLMMVESLRLYLGAGLHSWVYLRGCNVNEDKEIPA---LSLSPCV 350

  Fly   284 ---------------------------HTAADKDYYVRV--RTVEDDIEDDL-PETIHPSIELNA 318
                                       |..:....||.|  .:|.|.:...| .|.:|.....:.
plant   351 FKISENEKVLDKGTDRLGNNNSVRKSSHPPSGLSTYVDVVDWSVHDKVVTALSSEGLHDEGNHDK 415

  Fly   319 N------LMKLLGIKELERVVLRPKTTVVNFVEKIELFANKKT--HYKIME-NAFKRF-----VI 369
            |      |.:|..:.:|:.:      ..|..|:...|...::|  |:::.. .::|..     |.
plant   416 NKKGLEYLTRLWSLAQLDAM------ASVTGVDVSSLIVGRETFFHFEVRGLESYKSIDGQPSVN 474

  Fly   370 ER------TQHKPMLFNQEEVVRLEDDLLVTVGILPEHF---RYCVVDAQFLKESKIYAADLVRP 425
            :|      .:|.|:            ::|..:.:..|..   ::...|....:..|......:.|
plant   475 DRWESGKKDKHTPL------------EILYVMTVSDESLLGDKFAGYDLSLDRSEKSDNVVHIEP 527

  Fly   426 V------GEII----KEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMNLCLS-------ADNS 473
            |      ||.|    .:||.....:| .|:..|.....||..|::  ||.:.||       :...
plant   528 VLEKMNLGEPIYLKSAKETHCNKGVS-PDISSLTWMGPIVSDVIK--RMTVLLSPAAGMWFSKFK 589

  Fly   474 VMRQCNVLLAGASGTGKTVLVERILDQLSRKPD-YCHFEFFHGSRSKGRKTESIQKDLRNIFTSC 537
            :....::|:.|..|:|||:|..........:.| ..|......|.....|.:.|...|.::....
plant   590 IPSPGHILIYGPPGSGKTILARAAAKYFEEQKDLLAHVILVSCSTLALEKVQHIHHVLSSVIAEG 654

  Fly   538 LQHAPAIVVLENLDVLAHAA----GEQSSQDGEYYNRMADTVYQLIVQYTTNNA----IAVIATV 594
            |:|||::::|::||.:..::    |.|:|.......:....|.....:|..::.    :|.:|:|
plant   655 LEHAPSVIILDDLDSIISSSSDTEGTQASVGVTMLTKFLTDVIDDYGEYRNSSCGIGPLAFVASV 719

  Fly   595 NELQTLNKRLSSPRGRHVFQTVARLPNLERADREIILRELCSH--INVAKDLDLVKFSNLTEGYR 657
            ..|:.:.:.||| .||..|......|  ..::|..||:.....  ::.::|: |:..:...|||.
plant   720 QSLEQIPQTLSS-SGRFDFHVQLAAP--ATSERGAILKHEIQKRLLDCSEDI-LLNLAAKCEGYD 780

  Fly   658 KCDLVQFVERAIFYAYRISKTQPLLTNDQLIESLEHTNSYCLQG---IQSNQRTGNDADANEMRV 719
            ..||...|:||:..|  |.:..||.:|......::...:..:..   :.....|.:.::...:..
plant   781 AYDLEILVDRAVHAA--IGRHLPLESNISKYNLVKEDFTRAMHDFVPVAMRDITKSASEGGRLGW 843

  Fly   720 EELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIIS 784
            |::.|:..:...::|::..||::|.||..||||.::.||||||||.|||::|...|.:.:||.||
plant   844 EDVGGVTDIKNAIKEMIELPSKFPKIFAKSPLRLRSNVLLYGPPGCGKTHIVGAAAAACSLRFIS 908

  Fly   785 VKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDSTGVTDRVVNQLLTELD 849
            |||||||.||||.||:.||::|::|.:|.||:||||||||:|||||||:||||||||||.|||||
plant   909 VKGPELLNKYIGASEQAVRDIFSKAAAAAPCILFFDEFDSIAPKRGHDNTGVTDRVVNQFLTELD 973

  Fly   850 GVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDECVDFDW 914
            |||.|.||.|.||||||:||||||||.||:|||:.|..|..|.|:.|...||..|.:.:.:|.:.
plant   974 GVEVLTGVFVFAATSRPDLLDPALLRPGRLDRLLLCDFPSPPERLEILTVLSRKLLMADDIDLEP 1038

  Fly   915 FAGKTANYTGADIQSILTSANMAAVKEALAQFGH----------EKLAKKISLKQKHLIESFQTT 969
            .|..|..::|||:|::|:.|.:|||.|.|.:...          :.|.|.|:.|          |
plant  1039 IALMTEGFSGADLQALLSDAQLAAVHEYLNREDKPETGTTPIITDPLLKSIASK----------T 1093

  Fly   970 RPSLSASDVAKYHRTYARFTNKEKTSREFVAKRATLA 1006
            :||:|.::..|.:..|::|.:..|:|||...||||||
plant  1094 KPSVSETEKQKLYDIYSQFLDSRKSSREAKGKRATLA 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361	20/74 (27%)
		SpoVK	479..974	CDD:223540	189/518 (36%)
		P-loop_NTPase	480..604	CDD:304359	29/132 (22%)
		AAA	757..887	CDD:278434	94/129 (73%)
PEX1	NP_196464.2	PEX-1N	109..182	CDD:286361	20/72 (28%)
		SpoVK	585..1104	CDD:223540	190/534 (36%)
		AAA	589..>635	CDD:99707	10/45 (22%)
		AAA	881..1010	CDD:278434	93/128 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	190	1.000	Domainoid score	I951
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171861at2759
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto3003
orthoMCL	1	0.900	-	-		OOG6_103335
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830