DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex1 and pex1

DIOPT Version :9

Sequence 1:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001164306.1	Gene:	pex1 / 793906	ZFINID:	ZDB-GENE-070530-1	Length:	1237	Species:	Danio rerio

Alignment Length:	1088	Identity:	308/1088 - (28%)
Similarity:	500/1088 - (45%)	Gaps:	232/1088 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVYRPIRSNFVLLPDQYYGVVSTYDTGCLSLQYN-GRTHYASWAPQKGGGGIKDTEIGINARAAK 71
            :|:...::.|:.|...:...:..::...|.|.:. ....:.||...:..|  .:..:.|:.:..:
Zfish    12 LVFNNSKNCFLHLSSNFATHLCLHENQILELSWGVSAPVFLSWIRSRSSG--PEDRVEISRQLGE 74

  Fly    72 EIGLHENDLVKCALIADVLNLRSVHVTPVSSKDWEIIELSTEKISGSVLEQTRIVNSTQILIVWI 136
            ::||.:.:.........|.:::.|.|.|:|..||||:||.:..:...:|:|.|:|.|..:..||:
Zfish    75 KLGLRDGEQGYLRPCLQVQSVQQVSVEPLSPDDWEILELHSLALEQRILDQIRVVFSDGVFPVWV 139

  Fly   137 NKSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYKGLTNGTSNGVIEENTKLSRSKTTAQVKDE 201
            ::...:.:.:..|.|.:.|||::..|||:|:|.|:.|             ::|.....:.:.:..
Zfish   140 DQHTVIYIRIASLTPSVPYGRLEQFTELIVSPKLHPG-------------SELLHKPQSEEPRQH 191

  Fly   202 LTEKLTPLTHSSTVSNVKNTIQRNKRQDHMERLKK-------DLRRESSRSFEFRVIRGLW---R 256
            ....:|    ||::||.    .::.:.||.|.|.:       ||:         .::|.|:   |
Zfish   192 QNVNIT----SSSISNA----SQDSQNDHPESLNEGHWGGIADLK---------GLVRYLFTRGR 239

  Fly   257 EQAQESDVFVNGKHLPEFF-DLDLFYC--------MHTAADKDYYVRVRTVEDDIEDDLPETIHP 312
            |.|:|.   :....:|... |..|..|        .|.:...|.::....:::.      |..:|
Zfish   240 EPAKEK---IAVPTIPAILKDCILRTCGSPPRSVSHHGSCHGDVHILPWNLQEQ------ENWNP 295

  Fly   313 --SIELNANLMKLLGIKELERVVLRPKTTVVNFVEKIELFANK-KTHYKIMEN-AFKRFV---IE 370
              |......|.|:|..||     ||.|.......:||...::| |...:.||| |..|.:   |.
Zfish   296 GQSALTYGRLSKILSPKE-----LREKVKQAMEKKKIRDASHKEKDTEEHMENSAVVRMLCHNIN 355

  Fly   371 RTQHKPMLFNQEEVV------------RLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAADL- 422
            |.|....|...||:.            ||:.||...|.|.|            ||.....|..:
Zfish   356 RLQEDQKLNKCEEIYSGKIWIPKMLQRRLKIDLHSAVRIQP------------LKSMPRLAETVM 408

  Fly   423 ---VRPVGEIIKEE---------------TPPTSPLSVQDLIQLP------------------EY 451
               ::|:.|..|||               .|.|......::|.||                  :.
Zfish   409 VQPLQPLAESEKEEDIQMAFLNWFDAQSHQPLTCLTGRSNIILLPCAEGKEEFALTVLKPEQQQE 473

  Fly   452 DKI----------VD-QVVQELRMNLCLSADNSVMRQC--------------------------- 478
            |::          .| |:.:|...:....:||....||
Zfish   474 DELFFLSNSLLRKTDIQIAREPHNSDHRGSDNDTEDQCLGFPSLSSLGGVEDISRSAFQHISHAL 538

  Fly   479 -------------------NVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTE 524
                               .:|:.||.|:||:.|...:..:.|...| .|.:.......||::|:
Zfish   539 LGGSLSRELISTGRGLRGGALLITGAKGSGKSSLSRALCRKASEDLD-AHIQLLDCKTLKGKRTD 602

  Fly   525 SIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEY----------YNRMADTVYQLI 579
            :|::.|.::|...:...|::|:|::||   |.||..:|.:.|:          ...:.|.|.:::
Zfish   603 TIRQRLEDVFEQAVWRQPSVVLLDDLD---HVAGAATSPEHEHGPEAVLRQHISQSLKDLVDEIV 664

  Fly   580 VQYTTNNAIAVIATVNELQTLNKRLSSPRGRHVFQTVARLPNLERADREIILRELCSHINVAKD- 643
            ::   ::.||:|.|......|:..|:..:|.|.||:..::|..::|.|..||:.|.    |.|.
Zfish   665 LR---SSLIALIVTAQTEHALHPTLTVVQGSHFFQSFCKIPTPDQAQRVEILKSLI----VKKSF 722

  Fly   644 ------LDLVKFSNLTEGYRKCDLVQFVERAIFYAYRISKTQPLLTND--QLIESLEHTNSYCLQ 700
                  |||...:..|||:...||...:|||| :|..:..::.|...|  |.::.....:.:..|
Zfish   723 QVCQTTLDLDSVAKETEGFMARDLNLLLERAI-HANTLHNSEDLSCKDFRQALQGFTPPSLWDAQ 786

  Fly   701 GIQSNQRTGNDADANEMRVEELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGT 765
             :|:....|         :|.:.||.....:|.::::.|::||.:|::.|||..:||||||.|||
Zfish   787 -LQAPSGAG---------MERIGGLHEARQLLMDIILLPAKYPLLFSSLPLRQCSGVLLYGAPGT 841

  Fly   766 GKTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRG 830
            |||.|...:|....:..||:||||||:||||.||:.||::|.||:.|:||:|||||||||||:||
Zfish   842 GKTLLAGAVAKESGMNFISIKGPELLSKYIGASEQAVRDVFQRAQQAKPCILFFDEFDSLAPRRG 906

  Fly   831 HDSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVR 895
            ||:|||||||||||||:|||||||.||.|:||:|||:|:||||||.||:|:.:.||.||..||:.
Zfish   907 HDNTGVTDRVVNQLLTQLDGVEGLTGVYVLAASSRPDLIDPALLRPGRLDKSLYCPPPDREARLE 971

  Fly   896 IFEALSSTLSLDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEAL 943
            |..||:.::.|...||.|..||.|..:||||::::|.:|.:.|:..:|
Zfish   972 ILRALTHSVPLAADVDLDQIAGATELFTGADLKALLYNAQLEAIHSSL 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361	26/74 (35%)
		SpoVK	479..974	CDD:223540	189/484 (39%)
		P-loop_NTPase	480..604	CDD:304359	33/133 (25%)
		AAA	757..887	CDD:278434	89/129 (69%)
pex1	NP_001164306.1	PEX-2N	12..89	CDD:286362	11/78 (14%)
		PEX-1N	101..171	CDD:286361	24/69 (35%)
		SpoVK	559..1026	CDD:223540	189/483 (39%)
		P-loop_NTPase	559..686	CDD:304359	33/133 (25%)
		AAA	833..962	CDD:278434	88/128 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595707
Domainoid	1	1.000	191	1.000	Domainoid score	I3193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1938
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171861at2759
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto40505
orthoMCL	1	0.900	-	-		OOG6_103335
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3465
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900