Protein Alignment Pex1 and AFG2B

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_076968.2
• Gene: AFG2B / 79029
• HGNCID: 28762
• Length: 753
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 183/618 - (29%)
• Similarity: 295/618 - (47%)
• Gaps: 86/618 - (13%)

  Fly   420 ADLVRP------VGEIIKEETP-PTSPL--------SVQDLIQLPEYDKIVDQVVQELRMNLCLS 469
            |.||.|      .||...|..| |..||        |:::|::||            ||....|:
Human   175 AGLVTPRTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLP------------LRYPRALT 227

  Fly   470 ADNSVMRQCNVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIF 534
            |....:.: .|||||..|.|||.||..:..:...:..........||| .|...|::    |.:|
Human   228 ALGLAVPR-GVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSR-PGETEENV----RRVF 286

  Fly   535 TSCLQHA---PAIVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNE 596
            ....:.|   |:::.|:.:|.|....|.::.:     :|:...|..|:...:.:..:.|:...|.
Human   287 QRARELASRGPSLLFLDEMDALCPQRGSRAPE-----SRVVAQVLTLLDGASGDREVVVVGATNR 346

  Fly   597 LQTLNKRLSSPRGRHVFQTVARLPNLERADREIILRELCSHINVAKDLDLVKFSNLTEGYRKCDL 661
            ...|:..|..| ||...:.|...|.|::  |:.||:.:.|.:.::..:||...:.:|.||...||
Human   347 PDALDPALRRP-GRFDREVVIGTPTLKQ--RKEILQVITSKMPISSHVDLGLLAEMTVGYVGADL 408

  Fly   662 VQFVERAIFYAYRIS-KTQ--PLLTNDQLIESLEHTNSYCLQGIQSNQRTGNDADANEMRVEELP 723
            ......|..:|...| |.|  |::.....:|:.::......:.:....      |...:..||:.
Human   409 TALCREAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLM------DIKPVDWEEIG 467

  Fly   724 GLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKGP 788
            |||.|...|::.:.||.::|..|....|....|||||||||..||.||..||||.:...:||.|.
Human   468 GLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGA 532

  Fly   789 ELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDSTG--VTDRVVNQLLTELDGV 851
            :|.:.::|.||:.:..:|.:||::.|.:||.||.||:...|....||  |.:||::.||.|||||
Human   533 DLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGV 597

  Fly   852 EGL--------------------QGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRI 896
             ||                    :.|.:||||:||::||.||||.||:|:::..|.||...|:.|
Human   598 -GLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSI 661

  Fly   897 FEALSSTLSLDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEALAQFGHEKLAKKISLKQKH 961
            .:..:.|:.:...|..:..|.:|..::|||::::.|.|.:.|::        |......::||:|
Human   662 LKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQ--------ENGLDATTVKQEH 718

  Fly   962 LIESFQTTRPSLSASDVAKYHRTYAR--FTNKE 992
            .::|.:|.:||||..|:|.|...:.:  |:|.|
Human   719 FLKSLKTVKPSLSCKDLALYENLFKKEGFSNVE 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729
		CDC48	365..983	CDD:273521	180/605 (30%)
		RecA-like_PEX1_r2	728..885	CDD:410934	72/178 (40%)
AFG2B	NP_076968.2	Required for interaction with AFG2A and CINP. /evidence=ECO:0000269|PubMed:38554706	1..189		4/13 (31%)
		CDC48	22..746	CDD:273521	180/611 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..203		10/27 (37%)