Protein Alignment Pex1 and Iqca1

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001355651.1
• Gene: Iqca1 / 74918
• MGIID: 1922168
• Length: 838
• Species: Mus musculus
• Alignment Length: 709
• Identity: 140/709 - (19%)
• Similarity: 265/709 - (37%)
• Gaps: 194/709 - (27%)

  Fly    61 TEIGIN---ARAAKEIGLHENDLVKCALIADVL---NLRSVHVTPVSSKDWEIIELSTEKISGSV 119
            ||.|:|   ..|||.|.|.|  .||...||:..   .||::.:..:..::....|:   |:.|..
Mouse   143 TECGLNLPVKYAAKSIALEE--AVKLIQIAERARQGRLRALFMKQIFLQECRAKEM---KLLGHR 202

  Fly   120 LEQTRIVNSTQILIVWINKSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYKGLTNGTSNGVIE 184
            |..|::. :.||..|| ....|...||...:..|.:        |.:.|:   .|.|..|:.:::
Mouse   203 LLDTKLA-ALQIQKVW-RGFHQCKKTVKEREEEMVF--------LGMKPS---PLFNEVSDAIVQ 254

  Fly   185 ENTKLSRSKTTAQVKDELTEKLTPLTHSSTVSNVKNTIQRNKRQDHMERLKKDLRRESSRSFEFR 249
                   ||....::||:..| ....:...:.|:|..::..:..|..|.|:..:|:   ...|.|
Mouse   255 -------SKQVTNLRDEVQLK-HEQDYQEALVNIKEDLKMLEGPDIKEHLQDQIRQ---WFIECR 308

  Fly   250 VIRGLWREQAQESD-----VFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDDIED----- 304
            .:.|.:.:...|.|     :|.|  ..||....|:.    ...:::..::.:..::|.|:
Mouse   309 NLTGTFPDYPNEEDGGSALIFSN--KTPEQVMGDII----ATQEEEEKLKKKKKKEDKENKGKKG 367

  Fly   305 --DLPETIHPSIELNANLMKLLGIKELERVVLRPKTTVVNFVEKIE--------LFANKKTHYKI 359
              :..|.....:.|....||    .|.|...:.|..    |::.:|        ::.||...:..
Mouse   368 KKEKKEKKEKKVSLKEKAMK----DEDEEWKMSPSL----FLQLMEEGNSLYKDIWLNKDESWNF 424

  Fly   360 MENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYA-ADLV 423
            .::           :.|.|..:|:...||.::.|.|..|..         |.||..|:.. .::.
Mouse   425 PQD-----------YDPELIKEEKRKELEMEIRVQVDELMR---------QELKNLKLAVNREME 469

  Fly   424 RPV----------------GEIIKEETPPTSPLSVQDLIQLPEYDKIVDQ--VVQELRMNLC--- 467
            .|.                |:..|:|...|:..:::.|     |.::|::  ::|.|::||.
Mouse   470 IPPRQKKGKKKNKGRKGRRGKRGKKEKDLTADRTIESL-----YQELVEKGLLIQALKVNLSDYI 529

  Fly   468 --LSADNSVMRQC------------------------------------NVLLAGASGTGKTVLV 494
              .|...:.:||.                                    ::||||.||.||.:||
Mouse   530 GEYSYLGTTLRQVAIEPMPSLLDVRQLITLYGILPLGSAEVHERAPLVKSLLLAGPSGVGKKMLV 594

  Fly   495 ERILDQLSRKPDYCHFEFFHGS----RSKGRKTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAH 555
            ..|..:...       ..|:.|    ..|......:|..:..:|....|..|::|.:::.:...:
Mouse   595 HAICTETGA-------NLFNLSALNIAGKYPGKTGLQMMIHLVFKVARQLQPSVVWIQDTEKTFY 652

  Fly   556 AAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVN-----ELQTLNKRLSSPRGRHVFQT 615
            ....|:.:..| ..|:...:.:|:.....::.|.::.|.:     |||...:         |:|.
Mouse   653 KKVPQAEKRFE-PKRLKRYLPKLLKLLKPDDRILIVGTTHRPFDAELQPFCR---------VYQK 707

  Fly   616 VARLPNLERADR-----EIILR---ELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVE 666
            :..:|..:.|.|     |||||   :|.:.:|::      ..|.:|:|:.:..:||.::
Mouse   708 IILVPRPDYASRYVLWKEIILRNGGKLTNSLNIS------CLSKVTDGFTQGQIVQVIK 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	15/74 (20%)
		CDC48	365..983	CDD:273521	72/379 (19%)
		RecA-like_PEX1_r2	728..885	CDD:410934
Iqca1	NP_001355651.1	P-loop containing Nucleoside Triphosphate Hydrolases	552..711	CDD:476819	30/175 (17%)