DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pex1 and Nvl

DIOPT Version :10

Sequence 1:NP_652016.1 Gene:Pex1 / 45460 FlyBaseID:FBgn0013563 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_080447.1 Gene:Nvl / 67459 MGIID:1914709 Length:855 Species:Mus musculus


Alignment Length:872 Identity:227/872 - (26%)
Similarity:366/872 - (41%) Gaps:184/872 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   234 LKKDLRRESSRSFEFRVIRGLWREQAQESDVFVNG----KHLPEFFDLDLFYCMHTAA-----DK 289
            |..||:|..|..:..|. |..:|.|.::....::.    |:|.|..|      .|.|.     ::
Mouse    35 LASDLQRLYSVDYGRRK-RNAFRIQVEKVFSIISSEKELKNLKELED------GHLAKRARQDEE 92

  Fly   290 DYYVRVRTVEDDIEDDL--PETIHPSIELNANLMKLLGIKELERVVLRPKTTVVNFVEKIELFAN 352
            |.|....:.:|...:|.  |::.:|   :|::|:.|......|.|...||...........|..:
Mouse    93 DEYTESYSDDDSNMEDYPDPQSANP---MNSSLLSLYRRGNSESVSTTPKWGQREATTSTPLLTS 154

  Fly   353 K------KTHYKIMENAFKRFVIERT-----QHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCV 406
            |      ||..:..|..   :.|::|     :..|:..:.::....:.|                
Mouse   155 KTGSVPLKTPARESEGG---WFIDKTPGGKKESLPLDLSDDQSNSKKQD---------------- 200

  Fly   407 VDAQFLKESKIYAADLV---RPVGEIIKEETPPTSPL--SVQDLIQLPEYDKIVDQVVQELRMNL 466
            .:.|.||:|.:..:|..   |..|:..|.:|.....:  .::.|:|.....:..:..:..::...
Mouse   201 SEIQILKDSSLLESDKKRKGRAKGKGNKRKTENLQEVDGEIEALLQKKAKARSTELQISNVKFED 265

  Fly   467 CLSADNSVMRQC---------------------NVLLAGASGTGKTVLVERILDQLS------RK 504
            ....|.::...|                     .|||.|..|.|||:|...|..:|.      ..
Mouse   266 VGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAA 330

  Fly   505 PDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYN 569
            |:..          .|...||.|| ||.:|...:.:||.||.::.:|.:. ...|.:|:|.|   
Mouse   331 PEIV----------SGVSGESEQK-LRELFDQAVSNAPCIVFIDEIDAIT-PKREVASKDME--- 380

  Fly   570 RMADTVYQLIVQYTT-----NNAIA-----VIATVNELQTLNKRLSSPRGRHVFQTVARLPNLER 624
                  .:::.|..|     ||..|     ||...|...:|:..|.. .||...:....:|  :.
Mouse   381 ------RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRR-AGRFDREVCLGIP--DE 436

  Fly   625 ADREIILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVERAIFYAYR--ISKTQPLLTNDQL 687
            |.||.||:.||..:.:.:..:....::||.|:...||:.....|...|..  :.|.|........
Mouse   437 AARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKQQAQQKKKPE 501

  Fly   688 IESLEHTNSYCLQGIQSNQRTGND----------------ADANEMRVEELPGL----------- 725
            ||.|..      :|.| .:|.|.:                .|.:.:..|::.||           
Mouse   502 IEGLPS------EGDQ-EERLGAEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVAL 559

  Fly   726 ---------ESVV----------GVLEEV-------LMWPSRYPTIFNASPLRNQAGVLLYGPPG 764
                     |..|          |.||::       ::.|.|.|..|....|...||:||.||||
Mouse   560 AEVQPSAKREGFVTVPNVTWADIGALEDIRDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPPG 624

  Fly   765 TGKTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKR 829
            .|||.|...:|....|..|||||||||..|:|:||..||.:|.||:::.|||:||||.|:|.|:|
Mouse   625 CGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR 689

  Fly   830 GHDSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARV 894
            ....||.:.|||||||||:||:|..|.|.::|||:||:::|||:||.||:|:.:...||....||
Mouse   690 SDRETGASVRVVNQLLTEMDGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRV 754

  Fly   895 RIFEALSSTLS---LDECVDFDWFAG--KTANYTGADIQSILTSANMAAVKEALAQFGHEKLAKK 954
            .|.:.::...:   |||.|:.:..|.  :...|||||:.:::..|::.|:::.:....:...|.:
Mouse   755 AILKTITKNGTKPPLDEDVNLETIANDLRCNCYTGADLTALVREASLCALRQEITAQKNGVGAGE 819

  Fly   955 ISLKQKHLIESFQTTRPSLSASDVAKY 981
            :.:..||..::|:..:||:|..|...|
Mouse   820 LKVSHKHFEDAFKKVKPSISIKDQVMY 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pex1NP_652016.1 PEX-1N 93..168 CDD:462729
CDC48 365..983 CDD:273521 194/724 (27%)
RecA-like_PEX1_r2 728..885 CDD:410934 81/173 (47%)
NvlNP_080447.1 Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381 1..219 42/212 (20%)
Nucleolin_bd 2..72 CDD:465247 9/37 (24%)
Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449 49..52 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..234 32/172 (19%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 85..88 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 217..231 3/13 (23%)
CDC48 <242..855 CDD:273521 181/636 (28%)
Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381 266..473 54/230 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..523 7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

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