Protein Alignment Pex1 and Afg2a

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001156983.1
• Gene: Afg2a / 57815
• MGIID: 1927170
• Length: 893
• Species: Mus musculus
• Alignment Length: 975
• Identity: 252/975 - (25%)
• Similarity: 409/975 - (41%)
• Gaps: 222/975 - (22%)

  Fly    46 YASWAPQKGGGGIKDTEIGINARAAKEIGLHENDLVKC-ALIADVLNLRSVHVTPVSSKDWEIIE 109
            |.:| |..|..|.|   :|::..|.|.:|:...:.::. .|:..||..:.:.:. :|.||.||.|
Mouse    97 YTAW-PVAGFPGGK---VGLSEMAQKNVGVRAGETIQVQPLLGAVLQAQEMDLA-LSDKDKEINE 156

  Fly   110 LSTEKISGSVLEQT--RIVNSTQILIVWINKSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYK 172
               |:::|.:|.:.  :||.....|....                  |||:.....|.|     |
Mouse   157 ---EELTGCILRKLDGKIVLPGNFLYCTF------------------YGRLCKLQVLQV-----K 195

  Fly   173 GLTNGTSNGVIEENTKLSRSKTTAQ-VKDELTEKLTPLTHSSTVSNVKNTIQRNKRQDHMERLKK 236
            | |:||:.|.::     |.|.|.|| :..|         |||                 ||....
Mouse   196 G-TDGTTLGKLQ-----SASGTDAQGMASE---------HSS-----------------MESSDV 228

  Fly   237 DLRRESSRSFEFRVIRGLWREQAQESDVFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDD 301
            ||      ||:...: .|...|:..|      :..|         |..|        ..|||...
Mouse   229 DL------SFQLSQL-DLKEPQSPSS------QSTP---------CKPT--------NDRTVNKA 263

  Fly   302 IEDDLPETIHPSIELNANLMKLLGIK-------------ELERVVLRPKTTVVNFVEKIELFANK 353
            .|..|..|..|.......|.:..|:|             ..|..:|:|.:....        :|.
Mouse   264 GEVLLDVTQSPRDGSGLGLEESTGLKCSFDSSKEGNTQPVSEEKLLKPASAGTK--------SNT 320

  Fly   354 KTHYKIMENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIY 418
            .|.|.|....       |...:.:..|.:|                       .|:||    |:
Mouse   321 DTFYFISSTT-------RINLRKICTNSKE-----------------------QDSQF----KV- 350

  Fly   419 AADLVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMNLCLSADNSVMRQCNVLLA 483
            ..|::..:...:|         :::::|:||     :.|  .||..:..:.|..      .:||.
Mouse   351 TYDMIGGLNSQLK---------AIREIIELP-----LKQ--PELFKSYGIPAPR------GLLLY 393

  Fly   484 GASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPAIVVLE 548
            |..|||||::...:.:::.     .:....:|.....:.....:..||.||.......|:|:.::
Mouse   394 GPPGTGKTMIARAVANEVG-----AYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFID 453

  Fly   549 NLDVLA-HAAGEQSSQDGEYYNRMADTVYQL---IVQYTTNNAIAVIATVNELQTLNKRLSSPRG 609
            .||.|. ...|.||    |...|:..::..|   |....:...:.|:...|..|.|:..|..| |
Mouse   454 ELDALCPKREGAQS----EVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRP-G 513

  Fly   610 RHVFQTVARLPNLERADREIILRELCSHI-NVAKDLDLVKFSNLTEGYRKCDLVQFVERAIFYAY 673
            |...:....:||.:  ||..||::|...: ::....:|::.:|...||...||......|..:|.
Mouse   514 RFDKEIEIGIPNAQ--DRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHAL 576

  Fly   674 -RISKTQPLLTNDQLIESLEHTNSYCLQGIQSNQRTGNDADANEMRV----------EELPGLES 727
             |:.:.||.|.:.::...::.|.:..|||:       ||...:.||.          .::.|||:
Mouse   577 RRVLRKQPNLPDSKVAGMVKITLNDFLQGM-------NDIRPSAMREVAIDVPNVSWSDIGGLEN 634

  Fly   728 VVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKGPELLA 792
            :...|::.:.||.::|..||...::...|||||||||..||.:...||....|..:::|||||:.
Mouse   635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 699

  Fly   793 KYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDS--TGVTDRVVNQLLTELDGVEGLQ 855
            ||:|:||..||.:|.:||:..|.::||||.|:||.:||..|  ..|.|||:.|||||:||:|.|:
Mouse   700 KYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLK 764

  Fly   856 GVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDECVDFDWFAGKTA 920
            .|||:|||:||:.:|.||:|.|||||::..|||||..|..|......::.:...||.|....:|.
Mouse   765 NVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTD 829

  Fly   921 NYTGADIQSILTSANMAAVKEALAQFGHEKLAKKISLKQKHLIESFQTTRPSLSASDVAKYHRTY 985
            .|:||:|.::...|.:.|::|.:         |...:.::|..::.....|.:..| :.:::..|
Mouse   830 TYSGAEIIAVCKEAALLALEENI---------KADCIMKRHFTQALSIVTPRIPES-LRRFYEDY 884

  Fly   986  985
            Mouse   885  884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	17/76 (22%)
		CDC48	365..983	CDD:273521	177/635 (28%)
		RecA-like_PEX1_r2	728..885	CDD:410934	76/158 (48%)
Afg2a	NP_001156983.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:451359	10/38 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..227		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..315		19/98 (19%)
		CDC48	<323..889	CDD:273521	180/648 (28%)